【摘要】 目的 评估雷贝拉唑和奥美拉唑三联疗法2周治疗50例Hp阳性的消化性溃疡的愈合率及观察根除幽门螺杆菌的疗效。方法 50例Hp阳性的消化性溃疡患者，随机分为治疗组和对照组。两组均先给予三联治疗(雷贝拉唑10mg或奥美拉唑20mg+阿莫西林1.0g+克拉霉素500mg，每天2次)，连服7天，然后单独给予雷贝拉唑10mg或奥美拉唑20mg，每天1次，连服7天，用药结束后第4～6周复查内镜并复查Hp。记录副作用。计算用药成本及费用效果(C/E)。结果 治疗组、对照组Hp根除率分别为88%、72%(P>0.05)，C/E分别为 8.73、9.25。溃疡的愈合率分别为92%、64%(P<0.01)，C/E分别为 8.35、10.62。副作用发生率分别为12%和20%。结论 雷贝拉唑2周三联疗法，是一种短程、高效、安全、更为经济的根除Hp及促进溃疡愈合的方案。

    【关键词】 雷贝拉唑;幽门螺杆菌;消化性溃疡

    【Abstract】 Objective To evaluate the efficacy of rabeprazole and omeprazole based triple therapy regimens in the treatment of Helicobacter pylori related ulcer.Methods 50 cases with documented peptic ulcer and Hp infection by endoscopic examination and rapid urease test were randomized to receive rabeprazole or omeprazole based triple therapy regimens for 14days.Endoscopic examination and rapid urease test were repeated four-six weeks after the end of the treatment ......