[摘要] 目的 观察奥曲肽联合奥美拉唑治疗肝硬化并上消化道出血的疗效。方法 将96例肝硬化并上消化道出血患者，分为A组(49例)和B组(47例)，A组采用奥曲肽和奥美拉唑联合治疗，B组单用奥曲肽治疗，并观察相关指标。 结果 A组48 h再出血率(10.20%)明显低于B组(27.65%)，P<0.05；A组住院天数[(5.13±2.45)天]明显少于B组[(7.56±2.83)天]，P<0.05；A组输血量[(3.56±2.25)u]与B组[(3.75±2.12)u]比较差异无显著性(P>0.05)；A、B两组死亡率无明显差异(P>0.05)。 结论 奥曲肽联合奥美拉唑治疗肝硬化并上消化道出血，能有效预防早期再出血发生和缩短住院天数。

    [关键词] 肝硬化;上消化道出血;奥曲肽;奥美拉唑

    Efficacy of octreotide combined with omeprazole on cirrhotic patients with upper gastrointestinal hemorrhage

    LI Hong-tao,PENG Ya,LIU Fen,et al.Department of Gastroenterology,the Third Xiangya Hospital,Central South University,Changsha 410013,China

    [Abstract] Objective To observe efficacy of octreotide combined with omeprazole in cirrhotic patients with upper gastrointestinal hemorrhage. Methods Ninty-Six cases of liver cirrhosis with upper gastrointestinal hemorrhage were divided into group A (49 cases) and group B (47 cases).Group A was assigned to receive octreotide plus omeprazole,while group B was treated with octreotide alone. Results Rebleeding rate after the first 48 hours of group A(10.20%) was significantly less than that of group B(27.65%) P<0.05;Group A had a better short hospital stay,5.13±2.45 vs 7.56±2.83 days (P<0.05) as compared with group B ......