ABSTRACTS ORIGINAL ARTICLES
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中华医学杂志931033 Antigen mimicry of anti-idiotypic antibodies for human ovarian carcimoma antigen: generation and characterization of anti-anti-idiotype antibodies. Lu Wenying, Qian Henian. Research Laboratory of Gynecologic Oncology, People's Hospital, Beijing Medical University, Beijing 100044
The antigen mimicry of monoclonal anti-idiotypic antibodies 6B11 and 1H12 was investigated, which carring the internal image of human ovarian carcinoma antigen. Anti-anti-idiotypic antibodies, obtained form the mice immunized with 6B11 or 1H12, binded to ovarian tumor antigen OC 166-9 specifically by enzyme linked immunosorbent assay (ELISA). Western blot analysis showed that Ab3 and Ab1 recognized the same antigenic protein. Through antibody dependent cell-mediated cytotoxicity (ADCC), Ab3 sera killed the ovarian carcinoma cell line SKOV3 specifically in vitro. These results suggest that 6B11 and 1H12 may substitute for the nominal antigen to stimulate a specific immune response and that they are potential candidates as idiotype vaccines against ovarian carcinomas.
, 百拇医药
Key words Ovarian carcinoma Antigen Antibody monoclonal
(Original artical on page 581)
Cytomegalovirus inrection from mothers to their infants. Wang Huiying, et al. Capital Institute of Pediatrics, Beijing 10020
HCMV infection among mothers and their infants was studied prospectively with methods of hihg specificity and sensitivity, such as detection of HCMV specific IgM antibody captured by anti-μ chain antibody, rapid detection of HCMV early antigens from tissue cultures, etc. The data indicated that 94.6% of the pregnant women had been infected before their pregnancy. The rate of primary infection during pregnancy was only 0.13% according to the seroconversion of HCMV-IgM, suggesting that most of the active infection in pregnant women are due to reactivation of the virus, The congenital infection rate was 6.2%. Most of the women infected were asymptomatic and closely related to the maternal HCMV-IgM. It seems that most of the congenital infections are the result of recurrent infection of their mothers and maternal antibodies do protect the fetus. The presence of HCMV in mother's genital tracts was associated with perinatal infection but not congenital infections.
, 百拇医药
Key words Cytomegalovirueses Pregnancy complications, infectious Neonatal diseases and abnormalities
(Original artical on page 584)
The relationship between maternal age and neonatal physical development. Wang Baoqiong, et al. First Teaching Hospital, Hunan Medical University, Changsha 410008
24 150 newborn infants their mothers from 15 cities were investigated by analysing maternal age, neonate birth weight, length, head circumference, chest circumferece, crown-hip length and arm circumference so as to find out scientific evidences for encouraging women to be pregnant at a mature age and improving birth quality. The women aged 20 or younger showed that the physical development indexes of their babies were lower as compared with the women aged 21 or older, and the percentage of mature infant was lowest as compared with the other age grups. In contrast, women aged 24～34, the neonatal physical development indexes were the best and percentage of premature and postmature infants were the lowest, especially in the 24～29 age froup.
, http://www.100md.com
Key words Infants, newborn Growth Maternal age
(Original artical on page 587)
Detection of human papillomavirus DNA and clincopathological study of vulvar HPV inrection. fan Shangrong, et al. Department of Obstetrics and Gynecology, First Clinical School of Medicine, Beijing Medical University, Beijing 100034.
We studied 217 vulvar HPV infection patients by clinically, pathologically, and virologically. From 90.6% of the cauliflowerlike vulvar lesions and 29.7% of the papillomatous and fingerlike lesions, we detected HPV 6/11DNA by dot blotting hybridizition. The patients in 90.0% of the cauliflowerlike group and 9.8% of the papillomatous and fingerlike group had a hihg risk factor to intercourse with different sex partners(P<0.0001). The pathological characteristics, nature history, and response to treatment were different. According to clinical, pathological, and virological findings to clinical, pathological, and virological findings divided three types: vulvar HPV infection type 1 (or condylomata acuminata), vulvar HPV infection type 2, and vulvar HPV infection type 3.
, 百拇医药
Key words Vulva Papillomaviruses Pathology, clinical
(Original artical on page 590)
Electroacupuncture in treatment of spinal spasticity: effects and mechanism. Yu Yuan, et al. Depqrtment of Orthopedic Surgery, First Teaching Hospital, Beijing Medical University. Beijing 100034
To study the effect and mechanism of electrical stimulation in treating spinal spasticity, we used electroacupuncture (EA) on the surface of 2 couples of acupoints. The short term application (30 min) of high-frequency EA (100Hz)produced an immediate antispastic effect in contrast to the low-frequency EA (2Hz). After application of high-frequency EA (2 times/day, 30min/time) for 3 months, antispastic effect was stable. to keep this antispastic effect, the high-frequency EA must be used permanently. Recent experimental results showed that low and high frequency EA release MEK and dynorphin respectively from the spinal cord in humans. We infer that by enhencing the production of dynorphin in CSF, high-frequency EA decrease the excitibility of the motor neurons in the anterior horns through the kappa opiate receptors, thus ameliorating the muscle spasticity of spinal origin.
, 百拇医药
Key words Muscle spasticity Electric stimulation Acupuncture
(Original artical on page 593)
The tangential X-ray investigation of mormal patelloremoral joint. Zhang Guangbo. Department of Orthopaedic Surgery, China-Japan Friendship Hospital, Beijing 100029
From May 1990 to June 1991, we studied 80 asymptomatic volunteers aged from 18 to 40 years by using axial roetgenograms of the patellofemoral joint, which were taken with Laurin technique, but knee in 30 degree of flexion. Six parameters obtained through radiographic mesurements incluede sulcus angle, congruence angle, lateral patella displacement, patellofenoral index, lateral patellofmoral angle and tilting angle of patella. Radiographic mesurements of normal patellofmoral joint are helpful in the diagnosis of patellofemoral joint disease, and provide objective anatomical evidences for surgical treatment. Among the various prameters, congruence angle and lateral patellofemoral angle are more important.
, 百拇医药
Key words Patellofemoral joint X-rays
(Original artical on page 596)
The prevention and antibiotic treatment of pseulomonas aerginosa septicemia. Deng Guohua, et al. Peking Union Medical College Hospital, Beijing 100730
Thirty-six cases of pseudomonas aeruginosa septicemia were found in 5 years from 1986 to 1990. The main risk factors predisposing septicemia included severe underlying diseases and local primary inrection or impaired anatomic barrier. The use of broad-spectrum antibiotics, cytotoxic or immunosuppressive therapy, and leukopenia were also important risk ractors. The percentages of invitro resistant strains to 8 antipseudomonal antibiotics varied from 18% to 47%. The overall effective rate was 42% in 26 patients receiving appropriate antibiotic therapy. The mortality attributable to pseudomonas aeruginosa septicemia was 61%. The prevention and antibiotic treatment of pseudomonas aeruginosa septicemia are discussed.
, http://www.100md.com
Key words Septicemia Pseudomonas
(Original artical on page 599)
Randomised comparison on the treatment of falciparum malaria with dithdroartemisinin and piperaquine. Guo Xingbo, et al. Sanay Tropical Medicine Institute Guangzhou College of Traditional Chinese Medicine, guangzhou 510407
In 1988, 50 cases each of falciparum malaria were treated by dihydroartemisin (360 mg in 5 days and 480mg in 7 days respectively), and compared randomly with piperaquine phosphate group. The results showed that the plasmodium of falciparal malaria in Dong Fang County, Hainan province, is much more resistant to piperaquine phosphate, in the 51 cases treated by piperaquine, 33.3% were sensitive, 19.0% were RⅠ, 21.6% were RⅡ, and 25.5% were RⅢ. The effect of dihydroartemisinin (both 5 days and 7 days therapy) were obviously tetter than that of pipera quine, fever subsidence time and parasite clear ance time were similar and parasite recrudescence rate showed no obvious difference in these two groups too.
, 百拇医药
Key words Plasmodium falciparum Dihydroatemisnin Quinolinonew Drug evaluation
(Original artical on page 602)
Application of RT-PCR in rapid diagnosis and serotype identification of dengue virus inrection. Li Gang, et al. Department of In fectious Disease, Sun Yat-sen University of Medical Sciences, Guangzhou 510630
RT-PCR was developed for the amplification of partial E genome fragment from four dengue serotypes. Of the six oligonucleotide primers designed one was shared by dengue virus type 1 and type 2, and one by type 3 and type 4. Each of the other four primers was typespecific. Amplified products with 240, 150, 333 and 421bp, respectively were identified by electrophoresis on 2% angarose gel and digestion with restriction enzyme Hind Ⅲ. RT-PCR can detect dengue viral RNA from at least 5TCID50 virus, which was confirmed by detection of serial dilutions of culture supernatants. RT-PCR was also applied to serum samples from 60 acute patients. The findings showed that RT-PCR was of the same specificity as isolation of virus, followed by indirect fluorescent antibody tests. RT-PCR was more sensitive than cell culture and can be used for the rapid diagnosis and serotype identification of dengue virus infections.
, 百拇医药
Key words Dengue virus DNA Polymerase chain reaction Diagnosis, differential
(Original artical on page 605)
Detection of HFV-RNA in renal tissue and peripheral blood of patients with renal syndrome. Shen Keqin, et al. Research Institute of Nephrology, Jinling Hospital, Nanjing 210002
Hemorrhagic fever virus (HFV) RNA in renal tissue and blood samples from 21 patients with epidemic hemorrhagic fever with renal syndrome (HFRS) were examined by either in situ of blot hybridization using digoxgenin labelled HFV-cDNA probe. HFV associated antigen and immune complex(IC) in renal tissue were also investigated simultaneously using immunofluorescence(IF) technique. HFV-RNA was detected in the renal specimen particularly renal tubular in 8/21 HFRS patients mostly of severe type illness. However, the deposition of IC in the renal tissue in this group of patients occured mainly in the mild type apparently in a different manner of HFV-RNA. We conclude that both the HFV-RNA and immune complexs deposition are contributable to the pathogenesis of renal lesion in HFRS.
, http://www.100md.com
Key words Hemorrhagic fever Hybridization Viruses
(Original artical on page 609)
The model and results of intervention trial of stroke risk factors in Changsha. Yang Qidong, et al. Department of Neurology, xiangya Hospital, Hunan Medical Univer-sity. Changsha 410008
To develop an effective method for minimizing the incidence and mortality of cerebrovascular disease, we studied the sample population of intervention community (8 052 subjents) and control community (8 065 subjents) in Changsha. 2 631 subjents in the in-tervention community and 2 733 subjents in the confrol community with age more than 35 year were enrolled for a cohort study from January 1, 1986 to December 31, 1990. the annual incidence of stroke was 315/105 in the control community and 220/105 in the intervention community. The annual incidence of stroke was significantly lower in the intervention community than in the control community (P<0.01). The incidence of stroke in 1990 dropped by 66.4% compared to that in 1986 in the intervention community. But, in the control community it dropped by 9.7%. The change of the mortality and incidence of stroke in the two communities was similar.
, http://www.100md.com
Key words Stroke Morbidity Mortality
(Original artical on page 612)
Thromboxane and prostacyclin imbalance in the pathogenesis of early damage after severe burns Huang Yuesheng, et al. Burn Institute, Southwestern Hospital, Third Military Medical Cooege, Chongqing 630038
To define the pathogenesis of hemodynamical and hemorrheological changes as well as multiple organ failure(MOF)during early postburn stage, we determined the levels of thromboxane A2(TXA2) and prostacyclin (PGI2) and some other related variables in 57 patients, of which 14 were complicated by MOF. The results showed TXA2/PGI2 ratio increased markedly within 3 days postburn, and its dynamic change parallelled well with changes of hemod-ynamical and hemorrheological parameters as well as myocardial enzyme spectrum. both plasma and visceral levels of TXA2/PGI2 ratio were significantly higher in MOF than those in non-NOF cases. The altered TXA2/PGI2 ratio coincided with the clinical course of MOF patients. These findings suggested that TXA2/PGI2 imbalance may be one of the important factors of early postburn damage.
, http://www.100md.com
Key words burns Multiple organ failure Thromboxane A2 Prostaglandins X
(Original artical on page 615)
Aluminium toxicity to bone rabbits. Huang Guowei, et al. Department of Nutrition and Food Hygiene, Tianjin Medical College, tianjin 300070
Rabbits were used to study the toxic effects of A1 on their skeleton. The A1 content and PTH level were incerased along with A1 intake increase, and there was positive correlation between them (P<0.01). Bone Ca and P contents were increased with A1 intake increase, but serum Ca lever was decreased. Pathological examination of decalcified bone sections revealed no apparent changes between test and control groups. Histmorphometric results of undecalcified bone sections showed that osteoid of low and high A1 intake grops tenede to increase, mineralization process of hith A1 intake group was inhibited, and bone tissue formation of low A1 intake group tended to increase.
, 百拇医药
Key words Aluminum Bone and bones toxicology
(Original artical on page 618)
Noradrenaline release induced by electrical field stimulation during ischemia and reperfusion in rat hearts Feng Yibai, et al. Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022
The effects of the electrical field stimulation (6 Hz 5 v 2ms)on noradrenaline (NA) release during cardiac ischemia and reperfusion were studied in isolated perfused rat hearts. Endognous NA was measured by high pressure liquid chromtography. Reproducable release during two subsequent stimulations(S1,S2)in all preparations showed that electrical field stimulation is a sufficient method for inducing exocytotic NA release. Ischemic periods of 10 min reduced markedly NA overflow from rat hearts(S1/S2=0.34,P<0.01),while during the subsequent reperfusion period this suppression was abolished. These revented by the endogenous inhititor during early ischemia, a protective mechanism in early myocardial ischemis.
Key words Myocardium Perfusion Noradrenaline Animals, experimental
(Original artical on page 622), 百拇医药
单位：
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中华医学杂志931033 Antigen mimicry of anti-idiotypic antibodies for human ovarian carcimoma antigen: generation and characterization of anti-anti-idiotype antibodies. Lu Wenying, Qian Henian. Research Laboratory of Gynecologic Oncology, People's Hospital, Beijing Medical University, Beijing 100044
The antigen mimicry of monoclonal anti-idiotypic antibodies 6B11 and 1H12 was investigated, which carring the internal image of human ovarian carcinoma antigen. Anti-anti-idiotypic antibodies, obtained form the mice immunized with 6B11 or 1H12, binded to ovarian tumor antigen OC 166-9 specifically by enzyme linked immunosorbent assay (ELISA). Western blot analysis showed that Ab3 and Ab1 recognized the same antigenic protein. Through antibody dependent cell-mediated cytotoxicity (ADCC), Ab3 sera killed the ovarian carcinoma cell line SKOV3 specifically in vitro. These results suggest that 6B11 and 1H12 may substitute for the nominal antigen to stimulate a specific immune response and that they are potential candidates as idiotype vaccines against ovarian carcinomas.
, 百拇医药
Key words Ovarian carcinoma Antigen Antibody monoclonal
(Original artical on page 581)
Cytomegalovirus inrection from mothers to their infants. Wang Huiying, et al. Capital Institute of Pediatrics, Beijing 10020
HCMV infection among mothers and their infants was studied prospectively with methods of hihg specificity and sensitivity, such as detection of HCMV specific IgM antibody captured by anti-μ chain antibody, rapid detection of HCMV early antigens from tissue cultures, etc. The data indicated that 94.6% of the pregnant women had been infected before their pregnancy. The rate of primary infection during pregnancy was only 0.13% according to the seroconversion of HCMV-IgM, suggesting that most of the active infection in pregnant women are due to reactivation of the virus, The congenital infection rate was 6.2%. Most of the women infected were asymptomatic and closely related to the maternal HCMV-IgM. It seems that most of the congenital infections are the result of recurrent infection of their mothers and maternal antibodies do protect the fetus. The presence of HCMV in mother's genital tracts was associated with perinatal infection but not congenital infections.
, 百拇医药
Key words Cytomegalovirueses Pregnancy complications, infectious Neonatal diseases and abnormalities
(Original artical on page 584)
The relationship between maternal age and neonatal physical development. Wang Baoqiong, et al. First Teaching Hospital, Hunan Medical University, Changsha 410008
24 150 newborn infants their mothers from 15 cities were investigated by analysing maternal age, neonate birth weight, length, head circumference, chest circumferece, crown-hip length and arm circumference so as to find out scientific evidences for encouraging women to be pregnant at a mature age and improving birth quality. The women aged 20 or younger showed that the physical development indexes of their babies were lower as compared with the women aged 21 or older, and the percentage of mature infant was lowest as compared with the other age grups. In contrast, women aged 24～34, the neonatal physical development indexes were the best and percentage of premature and postmature infants were the lowest, especially in the 24～29 age froup.
, http://www.100md.com
Key words Infants, newborn Growth Maternal age
(Original artical on page 587)
Detection of human papillomavirus DNA and clincopathological study of vulvar HPV inrection. fan Shangrong, et al. Department of Obstetrics and Gynecology, First Clinical School of Medicine, Beijing Medical University, Beijing 100034.
We studied 217 vulvar HPV infection patients by clinically, pathologically, and virologically. From 90.6% of the cauliflowerlike vulvar lesions and 29.7% of the papillomatous and fingerlike lesions, we detected HPV 6/11DNA by dot blotting hybridizition. The patients in 90.0% of the cauliflowerlike group and 9.8% of the papillomatous and fingerlike group had a hihg risk factor to intercourse with different sex partners(P<0.0001). The pathological characteristics, nature history, and response to treatment were different. According to clinical, pathological, and virological findings to clinical, pathological, and virological findings divided three types: vulvar HPV infection type 1 (or condylomata acuminata), vulvar HPV infection type 2, and vulvar HPV infection type 3.
, 百拇医药
Key words Vulva Papillomaviruses Pathology, clinical
(Original artical on page 590)
Electroacupuncture in treatment of spinal spasticity: effects and mechanism. Yu Yuan, et al. Depqrtment of Orthopedic Surgery, First Teaching Hospital, Beijing Medical University. Beijing 100034
To study the effect and mechanism of electrical stimulation in treating spinal spasticity, we used electroacupuncture (EA) on the surface of 2 couples of acupoints. The short term application (30 min) of high-frequency EA (100Hz)produced an immediate antispastic effect in contrast to the low-frequency EA (2Hz). After application of high-frequency EA (2 times/day, 30min/time) for 3 months, antispastic effect was stable. to keep this antispastic effect, the high-frequency EA must be used permanently. Recent experimental results showed that low and high frequency EA release MEK and dynorphin respectively from the spinal cord in humans. We infer that by enhencing the production of dynorphin in CSF, high-frequency EA decrease the excitibility of the motor neurons in the anterior horns through the kappa opiate receptors, thus ameliorating the muscle spasticity of spinal origin.
, 百拇医药
Key words Muscle spasticity Electric stimulation Acupuncture
(Original artical on page 593)
The tangential X-ray investigation of mormal patelloremoral joint. Zhang Guangbo. Department of Orthopaedic Surgery, China-Japan Friendship Hospital, Beijing 100029
From May 1990 to June 1991, we studied 80 asymptomatic volunteers aged from 18 to 40 years by using axial roetgenograms of the patellofemoral joint, which were taken with Laurin technique, but knee in 30 degree of flexion. Six parameters obtained through radiographic mesurements incluede sulcus angle, congruence angle, lateral patella displacement, patellofenoral index, lateral patellofmoral angle and tilting angle of patella. Radiographic mesurements of normal patellofmoral joint are helpful in the diagnosis of patellofemoral joint disease, and provide objective anatomical evidences for surgical treatment. Among the various prameters, congruence angle and lateral patellofemoral angle are more important.
, 百拇医药
Key words Patellofemoral joint X-rays
(Original artical on page 596)
The prevention and antibiotic treatment of pseulomonas aerginosa septicemia. Deng Guohua, et al. Peking Union Medical College Hospital, Beijing 100730
Thirty-six cases of pseudomonas aeruginosa septicemia were found in 5 years from 1986 to 1990. The main risk factors predisposing septicemia included severe underlying diseases and local primary inrection or impaired anatomic barrier. The use of broad-spectrum antibiotics, cytotoxic or immunosuppressive therapy, and leukopenia were also important risk ractors. The percentages of invitro resistant strains to 8 antipseudomonal antibiotics varied from 18% to 47%. The overall effective rate was 42% in 26 patients receiving appropriate antibiotic therapy. The mortality attributable to pseudomonas aeruginosa septicemia was 61%. The prevention and antibiotic treatment of pseudomonas aeruginosa septicemia are discussed.
, http://www.100md.com
Key words Septicemia Pseudomonas
(Original artical on page 599)
Randomised comparison on the treatment of falciparum malaria with dithdroartemisinin and piperaquine. Guo Xingbo, et al. Sanay Tropical Medicine Institute Guangzhou College of Traditional Chinese Medicine, guangzhou 510407
In 1988, 50 cases each of falciparum malaria were treated by dihydroartemisin (360 mg in 5 days and 480mg in 7 days respectively), and compared randomly with piperaquine phosphate group. The results showed that the plasmodium of falciparal malaria in Dong Fang County, Hainan province, is much more resistant to piperaquine phosphate, in the 51 cases treated by piperaquine, 33.3% were sensitive, 19.0% were RⅠ, 21.6% were RⅡ, and 25.5% were RⅢ. The effect of dihydroartemisinin (both 5 days and 7 days therapy) were obviously tetter than that of pipera quine, fever subsidence time and parasite clear ance time were similar and parasite recrudescence rate showed no obvious difference in these two groups too.
, 百拇医药
Key words Plasmodium falciparum Dihydroatemisnin Quinolinonew Drug evaluation
(Original artical on page 602)
Application of RT-PCR in rapid diagnosis and serotype identification of dengue virus inrection. Li Gang, et al. Department of In fectious Disease, Sun Yat-sen University of Medical Sciences, Guangzhou 510630
RT-PCR was developed for the amplification of partial E genome fragment from four dengue serotypes. Of the six oligonucleotide primers designed one was shared by dengue virus type 1 and type 2, and one by type 3 and type 4. Each of the other four primers was typespecific. Amplified products with 240, 150, 333 and 421bp, respectively were identified by electrophoresis on 2% angarose gel and digestion with restriction enzyme Hind Ⅲ. RT-PCR can detect dengue viral RNA from at least 5TCID50 virus, which was confirmed by detection of serial dilutions of culture supernatants. RT-PCR was also applied to serum samples from 60 acute patients. The findings showed that RT-PCR was of the same specificity as isolation of virus, followed by indirect fluorescent antibody tests. RT-PCR was more sensitive than cell culture and can be used for the rapid diagnosis and serotype identification of dengue virus infections.
, 百拇医药
Key words Dengue virus DNA Polymerase chain reaction Diagnosis, differential
(Original artical on page 605)
Detection of HFV-RNA in renal tissue and peripheral blood of patients with renal syndrome. Shen Keqin, et al. Research Institute of Nephrology, Jinling Hospital, Nanjing 210002
Hemorrhagic fever virus (HFV) RNA in renal tissue and blood samples from 21 patients with epidemic hemorrhagic fever with renal syndrome (HFRS) were examined by either in situ of blot hybridization using digoxgenin labelled HFV-cDNA probe. HFV associated antigen and immune complex(IC) in renal tissue were also investigated simultaneously using immunofluorescence(IF) technique. HFV-RNA was detected in the renal specimen particularly renal tubular in 8/21 HFRS patients mostly of severe type illness. However, the deposition of IC in the renal tissue in this group of patients occured mainly in the mild type apparently in a different manner of HFV-RNA. We conclude that both the HFV-RNA and immune complexs deposition are contributable to the pathogenesis of renal lesion in HFRS.
, http://www.100md.com
Key words Hemorrhagic fever Hybridization Viruses
(Original artical on page 609)
The model and results of intervention trial of stroke risk factors in Changsha. Yang Qidong, et al. Department of Neurology, xiangya Hospital, Hunan Medical Univer-sity. Changsha 410008
To develop an effective method for minimizing the incidence and mortality of cerebrovascular disease, we studied the sample population of intervention community (8 052 subjents) and control community (8 065 subjents) in Changsha. 2 631 subjents in the in-tervention community and 2 733 subjents in the confrol community with age more than 35 year were enrolled for a cohort study from January 1, 1986 to December 31, 1990. the annual incidence of stroke was 315/105 in the control community and 220/105 in the intervention community. The annual incidence of stroke was significantly lower in the intervention community than in the control community (P<0.01). The incidence of stroke in 1990 dropped by 66.4% compared to that in 1986 in the intervention community. But, in the control community it dropped by 9.7%. The change of the mortality and incidence of stroke in the two communities was similar.
, http://www.100md.com
Key words Stroke Morbidity Mortality
(Original artical on page 612)
Thromboxane and prostacyclin imbalance in the pathogenesis of early damage after severe burns Huang Yuesheng, et al. Burn Institute, Southwestern Hospital, Third Military Medical Cooege, Chongqing 630038
To define the pathogenesis of hemodynamical and hemorrheological changes as well as multiple organ failure(MOF)during early postburn stage, we determined the levels of thromboxane A2(TXA2) and prostacyclin (PGI2) and some other related variables in 57 patients, of which 14 were complicated by MOF. The results showed TXA2/PGI2 ratio increased markedly within 3 days postburn, and its dynamic change parallelled well with changes of hemod-ynamical and hemorrheological parameters as well as myocardial enzyme spectrum. both plasma and visceral levels of TXA2/PGI2 ratio were significantly higher in MOF than those in non-NOF cases. The altered TXA2/PGI2 ratio coincided with the clinical course of MOF patients. These findings suggested that TXA2/PGI2 imbalance may be one of the important factors of early postburn damage.
, http://www.100md.com
Key words burns Multiple organ failure Thromboxane A2 Prostaglandins X
(Original artical on page 615)
Aluminium toxicity to bone rabbits. Huang Guowei, et al. Department of Nutrition and Food Hygiene, Tianjin Medical College, tianjin 300070
Rabbits were used to study the toxic effects of A1 on their skeleton. The A1 content and PTH level were incerased along with A1 intake increase, and there was positive correlation between them (P<0.01). Bone Ca and P contents were increased with A1 intake increase, but serum Ca lever was decreased. Pathological examination of decalcified bone sections revealed no apparent changes between test and control groups. Histmorphometric results of undecalcified bone sections showed that osteoid of low and high A1 intake grops tenede to increase, mineralization process of hith A1 intake group was inhibited, and bone tissue formation of low A1 intake group tended to increase.
, 百拇医药
Key words Aluminum Bone and bones toxicology
(Original artical on page 618)
Noradrenaline release induced by electrical field stimulation during ischemia and reperfusion in rat hearts Feng Yibai, et al. Institute of Cardiovascular Diseases, Tongji Medical University, Wuhan 430022
The effects of the electrical field stimulation (6 Hz 5 v 2ms)on noradrenaline (NA) release during cardiac ischemia and reperfusion were studied in isolated perfused rat hearts. Endognous NA was measured by high pressure liquid chromtography. Reproducable release during two subsequent stimulations(S1,S2)in all preparations showed that electrical field stimulation is a sufficient method for inducing exocytotic NA release. Ischemic periods of 10 min reduced markedly NA overflow from rat hearts(S1/S2=0.34,P<0.01),while during the subsequent reperfusion period this suppression was abolished. These revented by the endogenous inhititor during early ischemia, a protective mechanism in early myocardial ischemis.
Key words Myocardium Perfusion Noradrenaline Animals, experimental
(Original artical on page 622), 百拇医药