中老年女性乳腺分泌性癌
作者：宋敏 米小轶 高苏 宋继谒
单位：宋敏 米小轶 宋继谒(中国医科大学基础医学院病理教研室 110001)；高苏(沈阳医学院附属中心医院病理科)
关键词：乳腺；分泌性癌；幼年性癌
诊断病理学杂志000106摘 要：目的 研究乳腺分泌性癌的发病率、年龄和病理特点。方法 应用HE染色、淀粉酶消化后PAS及Alcianblue(AB)染色、透射电镜(TEM)方法观察。结果 乳腺分泌性癌仅占同期全部活检乳腺癌的0.6%。4例平均年龄54.5岁。病理形态学的主要特点为癌细胞异型性较小，癌细胞能产生大量分泌物，对PAS及AB染色出现阳性反应。术后12年随访，4例均无复发和转移。结论 乳腺分泌性癌为一种极少见的肿瘤，可发生于中老年女性，预后良好。根据其组织学特点，可以作出明确的病理诊断。
分类号：R737.9 文献标识码：A
, 百拇医药
文章编号：1007-8096(2000)01-0015-03
Secretory carcinoma of the breast in middle-aged women—A aeport of 4 cases
Song Min,Mi Xiaoyi,Gao Su
(Department of Pathology, College of Basic Medical Sciences China Medical University, Shenyang,110001)
Abstract：Objective To study the incidence,age,pathological features of secretory carcinoma of the breast. Methods Four cases of secretory carcinoma of the breast were collected from the archival material from 1973 to 1981. The specimens were stained with hematoxylin and eosin (HE),periodic acid-schiff (PAS) with diastase pretreatment and alcian blue (AB) and ob-served with transmission electronic microscope. Results Four cases of secretory carcinoma of the breast accounted for only 0.6 % (4/673) of the all breast carcinoma specimens in the same period.The average age was 54.5 (43～60 ).They were char-acterized by mild atypia of carcinoma cells and much secretory material in the cytoplasm positive for PAS and AB staining.The pa-tients were followed up for 12 years after surgical resection without recurrence and metastasis. Conclusions Secretory carcinoma was a rare tumor and the prognosis of the patients was very good.It couldoccur in middle-aged women.The pathological diagnosis could be made based on histological features of the tumor.
, http://www.100md.com
Keywords：Mammary gland Secretory carcinoma of the breast Juvenile secretory carcinoma of the breast
参考文献：
[1]Mcdivit RW，Stewart FW.Breast carcinoma in children.JAMA，1966，195：388
[2]杨堤，刘鸿瑞.乳腺分泌型癌.诊断病理学杂志，1994，1：26
[3]Mies C.Recurrent secretary carcinoma in Yesidual mammary tissue after mastectomy.Am J Surg Path，1993，17：715
[4]Tavassoli FA，Norris HJ.Secretory carcinonma of the breast.Cancer，1980，45：2404-2413
, http://www.100md.com
[5]Abe R，Masuda T.Secretory carcinoma of the breast in a Japanese woman.JRN J Surg，1986，16：52-55
[6]杉山和羲，坂元吾伟，秋山太，他.乳腺分泌癌の床病理学的检讨.乳癌の临床，1993，8：574
[7]西村令喜，丧尾和治，宫山束彦，他.乳房温存手术な施行した乳腺分泌癌の1例.乳癌の临床，1995，10：182
[8]Richard G，Hawk JC，Baker As，et al.Multiceatric adult secretory breast carcinoma:DNA flowcytoraetric findings,progmostic features，and review of the world literature.J Surg Oncol，1990,44：238
收稿日期：1999-06-23
修稿日期：1999-09-07, 百拇医药
单位：宋敏 米小轶 宋继谒(中国医科大学基础医学院病理教研室 110001)；高苏(沈阳医学院附属中心医院病理科)
关键词：乳腺；分泌性癌；幼年性癌
诊断病理学杂志000106摘 要：目的 研究乳腺分泌性癌的发病率、年龄和病理特点。方法 应用HE染色、淀粉酶消化后PAS及Alcianblue(AB)染色、透射电镜(TEM)方法观察。结果 乳腺分泌性癌仅占同期全部活检乳腺癌的0.6%。4例平均年龄54.5岁。病理形态学的主要特点为癌细胞异型性较小，癌细胞能产生大量分泌物，对PAS及AB染色出现阳性反应。术后12年随访，4例均无复发和转移。结论 乳腺分泌性癌为一种极少见的肿瘤，可发生于中老年女性，预后良好。根据其组织学特点，可以作出明确的病理诊断。
分类号：R737.9 文献标识码：A
, 百拇医药
文章编号：1007-8096(2000)01-0015-03
Secretory carcinoma of the breast in middle-aged women—A aeport of 4 cases
Song Min,Mi Xiaoyi,Gao Su
(Department of Pathology, College of Basic Medical Sciences China Medical University, Shenyang,110001)
Abstract：Objective To study the incidence,age,pathological features of secretory carcinoma of the breast. Methods Four cases of secretory carcinoma of the breast were collected from the archival material from 1973 to 1981. The specimens were stained with hematoxylin and eosin (HE),periodic acid-schiff (PAS) with diastase pretreatment and alcian blue (AB) and ob-served with transmission electronic microscope. Results Four cases of secretory carcinoma of the breast accounted for only 0.6 % (4/673) of the all breast carcinoma specimens in the same period.The average age was 54.5 (43～60 ).They were char-acterized by mild atypia of carcinoma cells and much secretory material in the cytoplasm positive for PAS and AB staining.The pa-tients were followed up for 12 years after surgical resection without recurrence and metastasis. Conclusions Secretory carcinoma was a rare tumor and the prognosis of the patients was very good.It couldoccur in middle-aged women.The pathological diagnosis could be made based on histological features of the tumor.
, http://www.100md.com
Keywords：Mammary gland Secretory carcinoma of the breast Juvenile secretory carcinoma of the breast
参考文献：
[1]Mcdivit RW，Stewart FW.Breast carcinoma in children.JAMA，1966，195：388
[2]杨堤，刘鸿瑞.乳腺分泌型癌.诊断病理学杂志，1994，1：26
[3]Mies C.Recurrent secretary carcinoma in Yesidual mammary tissue after mastectomy.Am J Surg Path，1993，17：715
[4]Tavassoli FA，Norris HJ.Secretory carcinonma of the breast.Cancer，1980，45：2404-2413
, http://www.100md.com
[5]Abe R，Masuda T.Secretory carcinoma of the breast in a Japanese woman.JRN J Surg，1986，16：52-55
[6]杉山和羲，坂元吾伟，秋山太，他.乳腺分泌癌の床病理学的检讨.乳癌の临床，1993，8：574
[7]西村令喜，丧尾和治，宫山束彦，他.乳房温存手术な施行した乳腺分泌癌の1例.乳癌の临床，1995，10：182
[8]Richard G，Hawk JC，Baker As，et al.Multiceatric adult secretory breast carcinoma:DNA flowcytoraetric findings,progmostic features，and review of the world literature.J Surg Oncol，1990,44：238
收稿日期：1999-06-23
修稿日期：1999-09-07, 百拇医药