乙型肝炎患者丁、戊、庚型肝炎病毒混合感染的临床探讨
作者：熊良仕 唐宁 常茂华
单位：川北医学院附属医院传染科(四川南充637000)
关键词：乙型肝炎；丁、戊、庚型肝炎病毒抗体；混合感染
重庆医学000406摘 要：目的探讨乙型肝炎患者丁、戊、庚型肝炎病毒感染情况及其混合感染对发病的影响。方法采用m法检测乙型肝炎患者血清中抗-HDVIgM、抗-HEVIgM和抗-HGVIgG并比较与临床间关系。结果各型乙肝患者中单纯HBV感染占69.9%(100/143)，混合感染占30.1%(43/143)；混合感染病例中，二重感染达95.3%(41/43)，三重感染占4.6%(2/43)；丁、戊、庚肝抗体阳性率分别为10.5%(15/143)、11.9%(17/143)和9.1%(13/143)；各型乙肝患者丁、戊、庚肝病毒混合感染率由高到低依次为重型乙型肝炎42.5%(17/40)、急性乙型肝炎36.4%(12/33)、慢性乙型肝炎20.8%(11/53)、乙肝肝硬化17.6%(3/17)；混合感染病例ALT、SB较低。结论乙型肝炎患者丁、戊、庚型肝炎病毒混合感染率较低，以二重感染常见；混合丁、戊、庚型肝炎病毒感染病例肝损轻、预后较好
, 百拇医药
Clinical Study of Co-infection of HDV, HEV and HGV in Patients with HBV Infection
Xiong Hangshi ,Tang Ning ,Chang Maohua
(D epartment of infectious Diseases, Affiliated Hospital of North Sichuan Moclical College, Nanchong, Sichuan Sichuan Province, 637000)
Abstract：Aim:To explore the prevalence of HDV, HEV and HGV infection and the effects of co-infection of HDV, HEV and HGV on pathcgenesis of viral hepatitis B. Methods:Anti-HDV IgM, anti-HEV IgM and anti-HGV IgG in serum were detected by EIA method.Results:The results showed that the prevalence rates of HDV, HEV and HGV were 10.5 96 (15/143), 11.9( 17/143)and 9.1% (13/143) respectively and that the co-infection rates were highest in patients with hepatic failure, lowest in patients with hepatitis cirrhosis, and that the patients with co-infection had milder damage to liver than that in patents with simple HBV infection. Conclusion:These data demonstrate that the prevalence of HDV,HEV and HGV are low in patients with hepatitis B virus infection; co-infection may play a role in the pathogenesis of hepatic failure and the cases with co-infection have a mild damage to liver and have a goed prognosis.
, 百拇医药
Keywords：Viral hepatitis; B Antibodies of HDV;HEV and HGV Co-infecfion
基金项目：此课题受四川省教委重大科研项目基金资助
参考文献：
[1]Linnen J，Wages J，Zhang-Keck ZY，et al.Molecular cloning and disease association of hepatitis G virus.a transmission transmissible agent.Science，1996，271：505
[2]Simons JN，Pilot-Matia TJ，Leary TP，et al.Identification of two flaviviirus-like genomes in the GB hhepatitis agent，proc Nail A-cad USA，1995，92：3401
, 百拇医药
[3]庄辉.我国庚型肝炎病毒的研究.中华肝脏病杂志，1998，6：3
[4]赵和平，赵素莲，张玲荣，等.庚型肝炎病毒与乙型、丙型肝炎病毒重叠感染的临床分析.中华实验和临床病毒学杂志，1997，11：389
[5]叶文华，程云，韩军，等.慢性病毒性肝炎患者抗庚型肝炎病毒抗体的检测与临床分析.中华实验和临床病毒学杂志，1997，11：393
[6]Alter HJ，Nakatsuji Y，Melpoder J，et al.The icidence of transfusion-associated hepatitis G virus infection and its relation and its relation to liver.NEJM，1997，336：747, 百拇医药
单位：川北医学院附属医院传染科(四川南充637000)
关键词：乙型肝炎；丁、戊、庚型肝炎病毒抗体；混合感染
重庆医学000406摘 要：目的探讨乙型肝炎患者丁、戊、庚型肝炎病毒感染情况及其混合感染对发病的影响。方法采用m法检测乙型肝炎患者血清中抗-HDVIgM、抗-HEVIgM和抗-HGVIgG并比较与临床间关系。结果各型乙肝患者中单纯HBV感染占69.9%(100/143)，混合感染占30.1%(43/143)；混合感染病例中，二重感染达95.3%(41/43)，三重感染占4.6%(2/43)；丁、戊、庚肝抗体阳性率分别为10.5%(15/143)、11.9%(17/143)和9.1%(13/143)；各型乙肝患者丁、戊、庚肝病毒混合感染率由高到低依次为重型乙型肝炎42.5%(17/40)、急性乙型肝炎36.4%(12/33)、慢性乙型肝炎20.8%(11/53)、乙肝肝硬化17.6%(3/17)；混合感染病例ALT、SB较低。结论乙型肝炎患者丁、戊、庚型肝炎病毒混合感染率较低，以二重感染常见；混合丁、戊、庚型肝炎病毒感染病例肝损轻、预后较好
, 百拇医药
Clinical Study of Co-infection of HDV, HEV and HGV in Patients with HBV Infection
Xiong Hangshi ,Tang Ning ,Chang Maohua
(D epartment of infectious Diseases, Affiliated Hospital of North Sichuan Moclical College, Nanchong, Sichuan Sichuan Province, 637000)
Abstract：Aim:To explore the prevalence of HDV, HEV and HGV infection and the effects of co-infection of HDV, HEV and HGV on pathcgenesis of viral hepatitis B. Methods:Anti-HDV IgM, anti-HEV IgM and anti-HGV IgG in serum were detected by EIA method.Results:The results showed that the prevalence rates of HDV, HEV and HGV were 10.5 96 (15/143), 11.9( 17/143)and 9.1% (13/143) respectively and that the co-infection rates were highest in patients with hepatic failure, lowest in patients with hepatitis cirrhosis, and that the patients with co-infection had milder damage to liver than that in patents with simple HBV infection. Conclusion:These data demonstrate that the prevalence of HDV,HEV and HGV are low in patients with hepatitis B virus infection; co-infection may play a role in the pathogenesis of hepatic failure and the cases with co-infection have a mild damage to liver and have a goed prognosis.
, 百拇医药
Keywords：Viral hepatitis; B Antibodies of HDV;HEV and HGV Co-infecfion
基金项目：此课题受四川省教委重大科研项目基金资助
参考文献：
[1]Linnen J，Wages J，Zhang-Keck ZY，et al.Molecular cloning and disease association of hepatitis G virus.a transmission transmissible agent.Science，1996，271：505
[2]Simons JN，Pilot-Matia TJ，Leary TP，et al.Identification of two flaviviirus-like genomes in the GB hhepatitis agent，proc Nail A-cad USA，1995，92：3401
, 百拇医药
[3]庄辉.我国庚型肝炎病毒的研究.中华肝脏病杂志，1998，6：3
[4]赵和平，赵素莲，张玲荣，等.庚型肝炎病毒与乙型、丙型肝炎病毒重叠感染的临床分析.中华实验和临床病毒学杂志，1997，11：389
[5]叶文华，程云，韩军，等.慢性病毒性肝炎患者抗庚型肝炎病毒抗体的检测与临床分析.中华实验和临床病毒学杂志，1997，11：393
[6]Alter HJ，Nakatsuji Y，Melpoder J，et al.The icidence of transfusion-associated hepatitis G virus infection and its relation and its relation to liver.NEJM，1997，336：747, 百拇医药