针灸对原发性骨质疏松症影响的实验和临床研究
作者：刘献祥 吴明霞 吴炳煌 章志安 钱松涛 李俐
单位：刘献祥 吴炳煌 章志安 钱松涛(福建中医学院，福建 福州 350003)；吴明霞 李俐(福建省第二人民医院，福建 福州)
关键词：骨质疏松；骨密度；针刺疗法
中国骨伤000903摘 要：目的探讨针刺和艾灸治疗原发性骨质疏松症的疗效。方法动物实验采用12月龄雌性大鼠65只，随机分为正常对照组、手术对照组、模型组、雌二醇组、针刺组和艾灸组；采用摘除双侧卵巢法建立骨质疏松症的模型，造模3个月后治疗3个月，进行骨代谢生化指标、性激素水平、骨小梁等观测针刺和艾灸的疗效。临床研究选择骨质疏松女性患者30例，随机分为针刺组和艾灸组各15例，治疗前和治疗3个月检查腰椎骨密度。结果经针刺、艾灸或雌二醇治疗后，S-AKP、U-Ca/Cr、U-HOP/Cr较模型组分别有所下降；S-E2、S-BGP较模型组升高(p<0.05～0.01)；骨小梁与髓腔的宽度比值，针刺、艾灸和雌二醇较模型组接近正常。30例骨质疏松患者骨密度治疗前和治疗后，针刺和艾灸组分别提高1.95%和2.43%。结论针刺、艾灸和雌二醇三者的作用无明显差异，针灸是防治骨质疏松症的有效方法之一。
, 百拇医药
Experimental and clinical studies of effects of acupuncture and moxibustion on primary osteoporosis
LIU Xian-sciang ,WU Ming-Ma ,WU Bing-huang
(Fujian College of TCM Fujian Fuzhou, 350003)
Abstract：Objective To explore experimental and clinical results of acupuncture and moxibustion for the treatment of primary osteoporosis. Methods 65 female S. D. rats aged 12 months were randomly divided into 6 groups: normal control group, Sham-cperated group, models group, estradiol group, acupuncture group, moxibustion group. Osteoporosis models were produced by bilateral ovariectomy. The treatment was carried out in models of 3 months and the treatment period lasted for 3 months. The effect of acupuncture and moxibustion was determined by the measurement of the biochemical indexes of bone metabolism, the level of sex hormone and bone morphometry. In the clinical tests,30 female cases of osteoporosis were randomly divided into two groups:acupuncture group and moxibustion group. Bone density of lumbar vertebral was determined at 3 months before treatment and after treatment. Results After the treatment, serum-AKP, Urine-Ca/Cr, UrineHOP/Cr in the estradiol group, acupuncture group and moxibustion group were significantly lower than in the model group;serum estradiol(E2), BGP in the estradiol group, acupuncture group and moxibustion group were significantly higher than those in the model group(p<0.05～0.01); the width ratio of bone trabecula to marrow cavity in the estradiol group, acupuncture group and moxibustion group was close to normal standard than that in the model group. Before and alter treatment,the bone density of 30 cases in the acupuncture group and moxibustion group raised 1.95% and 2.43% respectively. Conclusion There were no significant differents among the therapy of acupuncture, moxibustion and serum estradio. Acupuncture and moxibustion was effective way for the treatment and prevention of osteoporosis.
Keywords：Osteoporosis Bone density Acupuncture therapy
基金项目：福建省自然科学基金资助项目(No.C97049)
参考文献：
[1]柴本甫.绝经期后骨质疏松症的病理生理及治疗.中华骨科杂志，1984，4(1)：58-59.
收稿日期：1999-11-24
修稿日期：2000-03-27, 百拇医药
单位：刘献祥 吴炳煌 章志安 钱松涛(福建中医学院，福建 福州 350003)；吴明霞 李俐(福建省第二人民医院，福建 福州)
关键词：骨质疏松；骨密度；针刺疗法
中国骨伤000903摘 要：目的探讨针刺和艾灸治疗原发性骨质疏松症的疗效。方法动物实验采用12月龄雌性大鼠65只，随机分为正常对照组、手术对照组、模型组、雌二醇组、针刺组和艾灸组；采用摘除双侧卵巢法建立骨质疏松症的模型，造模3个月后治疗3个月，进行骨代谢生化指标、性激素水平、骨小梁等观测针刺和艾灸的疗效。临床研究选择骨质疏松女性患者30例，随机分为针刺组和艾灸组各15例，治疗前和治疗3个月检查腰椎骨密度。结果经针刺、艾灸或雌二醇治疗后，S-AKP、U-Ca/Cr、U-HOP/Cr较模型组分别有所下降；S-E2、S-BGP较模型组升高(p<0.05～0.01)；骨小梁与髓腔的宽度比值，针刺、艾灸和雌二醇较模型组接近正常。30例骨质疏松患者骨密度治疗前和治疗后，针刺和艾灸组分别提高1.95%和2.43%。结论针刺、艾灸和雌二醇三者的作用无明显差异，针灸是防治骨质疏松症的有效方法之一。
, 百拇医药
Experimental and clinical studies of effects of acupuncture and moxibustion on primary osteoporosis
LIU Xian-sciang ,WU Ming-Ma ,WU Bing-huang
(Fujian College of TCM Fujian Fuzhou, 350003)
Abstract：Objective To explore experimental and clinical results of acupuncture and moxibustion for the treatment of primary osteoporosis. Methods 65 female S. D. rats aged 12 months were randomly divided into 6 groups: normal control group, Sham-cperated group, models group, estradiol group, acupuncture group, moxibustion group. Osteoporosis models were produced by bilateral ovariectomy. The treatment was carried out in models of 3 months and the treatment period lasted for 3 months. The effect of acupuncture and moxibustion was determined by the measurement of the biochemical indexes of bone metabolism, the level of sex hormone and bone morphometry. In the clinical tests,30 female cases of osteoporosis were randomly divided into two groups:acupuncture group and moxibustion group. Bone density of lumbar vertebral was determined at 3 months before treatment and after treatment. Results After the treatment, serum-AKP, Urine-Ca/Cr, UrineHOP/Cr in the estradiol group, acupuncture group and moxibustion group were significantly lower than in the model group;serum estradiol(E2), BGP in the estradiol group, acupuncture group and moxibustion group were significantly higher than those in the model group(p<0.05～0.01); the width ratio of bone trabecula to marrow cavity in the estradiol group, acupuncture group and moxibustion group was close to normal standard than that in the model group. Before and alter treatment,the bone density of 30 cases in the acupuncture group and moxibustion group raised 1.95% and 2.43% respectively. Conclusion There were no significant differents among the therapy of acupuncture, moxibustion and serum estradio. Acupuncture and moxibustion was effective way for the treatment and prevention of osteoporosis.
Keywords：Osteoporosis Bone density Acupuncture therapy
基金项目：福建省自然科学基金资助项目(No.C97049)
参考文献：
[1]柴本甫.绝经期后骨质疏松症的病理生理及治疗.中华骨科杂志，1984，4(1)：58-59.
收稿日期：1999-11-24
修稿日期：2000-03-27, 百拇医药