Production of α-1,3-Galactosyltransferase Knockout Pigs by Nuclear Transfer Cloning
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1Department of Animal Science； 2Department of Veterinary Pathobiology； University of Missouri； Co
α-1|3-Galactosyltransferase|knockoutpig|cloning,Productionofα-1,3-GalactosyltransferaseKnockoutPigsbyNuclearTransferCloning
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1Department of Animal Science； 2Department of Veterinary Pathobiology； University of Missouri； Columbia； MO 65211； USA.3Immerge BioTherapeutics Inc.； Charlestown； MA 02129； USA. 4Department of Veterinary Medicine； College of AnimalResource Science； Kangwon National University； Chunchon 200-701； Korea. 5National Livestock Research Institute； Suwon441-350； Korea. Liangxue Lai；1 Donna Kolber-Simonds；3 Kwang-Wook Park；1 Hee-Tae Cheong；1；4 Julia L.Greenstein；3 Gi-Sun Im；1；5 MelissaSamuel；1 Aaron Bonk；1 August Rieke；1 Billy N. Day；1 Clifton N. Murphy；1 David B. Carter；1；2 Robert J. Hawley；3 Randall S.Prather1
关键词：α-1；3-Galactosyltransferase；knockout pig； cloning
摘要：The presence of galactose α-1,3-galactose residues on thesurface of pig cells is a major obstacle to successfulxenotransplantation. Here, we report the production offour live pigs in which one allele of the α-1,3-galactosyltransferase locus has been knocked out. Thesepigs, were produced by nuclear transfer technology basedon clonal fetal fibroblast cell lines as nuclear donors forembryos reconstructed with enucleated pig oocytes.
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