肠道多发性淋巴瘤性息肉病2例报告
作者：文锦 陈德忠 杨红 徐钢
单位：四川省人民医院病理科 成都 610072
关键词：肠肿瘤；淋巴瘤；息肉病；临床病理
诊断病理学杂志000210摘 要：目的探讨多发性淋巴瘤性息肉病(MLP)的临床病理特征及诊断要点。方法对2例肠道MLP的临床表现，病理组织学观察及免疫组化S-P法标记进行分析。结果2例均为50余岁男性，因便血作内镜检查，巨检发现肠粘膜多处息肉样肿块，直径0.4～4cm。组织学瘤细胞为一致性小淋巴细胞与小裂细胞之间的形态，围绕滤泡中心生长，致使大部分滤泡破坏消失。肿瘤局限于粘膜固有层及粘膜下层，不形成淋巴上皮病损。免疫组化：CD20、CD74、CD5阳性，单轻链λ表达。结论MLP是极罕见的胃肠道淋巴瘤，属套细胞淋巴瘤，看似分化良好，却有不良的临床预后。
分类号：R574 R733 文献标识码：A
, 百拇医药
文章编号：1007-8096(2000)02-0107-03
Intestinal Multiple Lymphomatous Polyposis：A Report of Two Cases
Wen Lin ,Chen Dezhong ,Yan Hong
(Deportment of Pathology，Sichuan Provincial People’s Hospital，Chengdu 610072)
Abstract：Objective To study the clinicopathological features and diagnostic criteria of multiple lymphomatous polyposis (MLP). Methods Clinical presentations，histopathology and immunohistochemistry of MLP were analyzed in 2 cases. Results Two male patients were in their sixties.There were multiple polyps (diameter from 0.4cm to 4 cm)in the intestinal mucosa on gross examination.Histologically，the tumor cells，which sizes were between small lymphocyte and small cleaved lymphoid cells，surrounded the germinal centers leading to atrophy or destruction of the most of them.The lesions were often limited in lamina propria and submucosa without lymphoepithelial lesions.Immunohistochemical stainings showed CD20+，CD74+，CD5+and Igλ light chain restriction in the lymphoid cells. Conclusiou MLP，as one of mantle cell lymphomas，was rare in the gastrointestinal tract.In spite of“low grade”morphology，its prognosis was very poor.
, 百拇医药
Keywords：Intestinal tumor Lymphoma Polyposis Clinicopathology
参考文献：
[1]张 霞，房殿春.肠道多发性淋巴瘤性息肉病1例.中华消化杂志，1998，18:219
[2]Lavergne A，Brouland JP，Launay E,et al.Multiple lymphomatous polyposis of the gastrointestinal tract.Cancer，1994,74:3042-3050
[3]Moynihan MJ，Bast MA，Chan WC，et al.Lymphomatous plyposis.Am J Surg Pathol，1996,20:442-452
, 百拇医药
[4]Ruskone-Fourmestraux A，Delmer A，Lavergne A，et al.Multiple lymphomatous polyposis of the gastrointestinal tract：Prospective clinicopathologic study of 3l cases.Gastroentesterology，1997,112:7-16
[5]Harris NL,Jaffe ES，Stein H，et al.A revised European-American classification of lymphoid neoplasms.Blood，1994,84:1361-1392
[6]Kumar S，Krenacs L，Otsuki T，et al.bcl-1 rearrangement and cyclin D1protein expression in multiple lymphomatous polyposis.Am J Clin Pathol，1996,105:737-743
, 百拇医药
[7]Smir BN，Kamaika CA，Cho CG，et al.Molecular evidence linke lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.Hum Pathol，1995,26:1282-1285
[8]Mahe B，Moreau A，Moreau P，et al.High dose radiochemotherapy followed by autologous stem cell transplantation in four patients with multiple lymphomatous polyposis.Cancer,1995,75:2742-2746
收稿日期：1999-10-22
修稿日期：1999-12-09, http://www.100md.com
单位：四川省人民医院病理科 成都 610072
关键词：肠肿瘤；淋巴瘤；息肉病；临床病理
诊断病理学杂志000210摘 要：目的探讨多发性淋巴瘤性息肉病(MLP)的临床病理特征及诊断要点。方法对2例肠道MLP的临床表现，病理组织学观察及免疫组化S-P法标记进行分析。结果2例均为50余岁男性，因便血作内镜检查，巨检发现肠粘膜多处息肉样肿块，直径0.4～4cm。组织学瘤细胞为一致性小淋巴细胞与小裂细胞之间的形态，围绕滤泡中心生长，致使大部分滤泡破坏消失。肿瘤局限于粘膜固有层及粘膜下层，不形成淋巴上皮病损。免疫组化：CD20、CD74、CD5阳性，单轻链λ表达。结论MLP是极罕见的胃肠道淋巴瘤，属套细胞淋巴瘤，看似分化良好，却有不良的临床预后。
分类号：R574 R733 文献标识码：A
, 百拇医药
文章编号：1007-8096(2000)02-0107-03
Intestinal Multiple Lymphomatous Polyposis：A Report of Two Cases
Wen Lin ,Chen Dezhong ,Yan Hong
(Deportment of Pathology，Sichuan Provincial People’s Hospital，Chengdu 610072)
Abstract：Objective To study the clinicopathological features and diagnostic criteria of multiple lymphomatous polyposis (MLP). Methods Clinical presentations，histopathology and immunohistochemistry of MLP were analyzed in 2 cases. Results Two male patients were in their sixties.There were multiple polyps (diameter from 0.4cm to 4 cm)in the intestinal mucosa on gross examination.Histologically，the tumor cells，which sizes were between small lymphocyte and small cleaved lymphoid cells，surrounded the germinal centers leading to atrophy or destruction of the most of them.The lesions were often limited in lamina propria and submucosa without lymphoepithelial lesions.Immunohistochemical stainings showed CD20+，CD74+，CD5+and Igλ light chain restriction in the lymphoid cells. Conclusiou MLP，as one of mantle cell lymphomas，was rare in the gastrointestinal tract.In spite of“low grade”morphology，its prognosis was very poor.
, 百拇医药
Keywords：Intestinal tumor Lymphoma Polyposis Clinicopathology
参考文献：
[1]张 霞，房殿春.肠道多发性淋巴瘤性息肉病1例.中华消化杂志，1998，18:219
[2]Lavergne A，Brouland JP，Launay E,et al.Multiple lymphomatous polyposis of the gastrointestinal tract.Cancer，1994,74:3042-3050
[3]Moynihan MJ，Bast MA，Chan WC，et al.Lymphomatous plyposis.Am J Surg Pathol，1996,20:442-452
, 百拇医药
[4]Ruskone-Fourmestraux A，Delmer A，Lavergne A，et al.Multiple lymphomatous polyposis of the gastrointestinal tract：Prospective clinicopathologic study of 3l cases.Gastroentesterology，1997,112:7-16
[5]Harris NL,Jaffe ES，Stein H，et al.A revised European-American classification of lymphoid neoplasms.Blood，1994,84:1361-1392
[6]Kumar S，Krenacs L，Otsuki T，et al.bcl-1 rearrangement and cyclin D1protein expression in multiple lymphomatous polyposis.Am J Clin Pathol，1996,105:737-743
, 百拇医药
[7]Smir BN，Kamaika CA，Cho CG，et al.Molecular evidence linke lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.Hum Pathol，1995,26:1282-1285
[8]Mahe B，Moreau A，Moreau P，et al.High dose radiochemotherapy followed by autologous stem cell transplantation in four patients with multiple lymphomatous polyposis.Cancer,1995,75:2742-2746
收稿日期：1999-10-22
修稿日期：1999-12-09, http://www.100md.com