作者单位：250011 济南，山东中医药大学(王雪)；250011 济南，山东中医药大学附属医院心内科(李晓)

    α7 烟碱型乙酰胆碱受体在心血管疾病中的研究进展

    王雪李晓

    【摘要】炎症在心血管疾病的发生和发展中起着关键的作用。最近研究表明，通过刺激迷走神经，激活胆碱能受体可以抑制促炎细胞因子释放，这一通路被称为“胆碱能抗炎通路”(CAP)。随着CAP的研究深入，其在心血管疾病防治中的地位备受关注，尤其是发挥核心作用的α7 烟碱型乙酰胆碱受体(α7nAChR)。该文就CAP和α7nAChR在高血压病、休克、急性心肌缺血再灌注等疾病中的作用进行综述，并对其在心血管疾病中潜在的临床意义进行讨论。

    【关键词】胆碱能抗炎通路；α7 烟碱型乙酰胆碱受体；心血管疾病；综述

    DOI:10.3969/g.issn.0253-9802.2015.02.002

    通讯作者，李晓，E-mail：lixiao617@163.com

    收稿日期：(2014-11-06)

    Research progress of α7 nicotinic acetylcholine receptor in cardiovascular diseasesWangXue，LiXiao.ShandongUniversityofTraditionalChineseMedicine,Jinan250011,China

    Correspondingauthor,LiXiao，E-mail:lixiao617@163.com

    Abstract【】Inflammation plays a key role in the incidence and development of cardiovascular diseases. Recent studies have shown that the release of pro-inflammatory cytokines could be suppressed by stimulating the vagus nerve and activate cholinergic receptors. This pathway is known as “cholinergic anti-inflammatory pathway” (CAP). Along with the in-depth studies related to CAP, the effect of such pathway, especially α7 nicotinic acetylcholine receptor (α7nAChR) which plays a central role in CAP, upon prevention and treatment of cardiovascular diseases has captivated more and more attention. In this paper, the role of CAP and α7nAChR in hypertension, shock, acute myocardial ischemia and reperfusion and other diseases was reviewed and the potential clinical significance was discussed. ......