作者单位： 510080 广州，中山大学附属第一医院妇产科

    脑衰反应调节蛋白-2在细胞迁移和非神经系统相关疾病中的研究

    范莉陈淑琴

    【摘要】脑衰反应调节蛋白-2(CRMP-2)是一种多功能调节蛋白，它不仅在哺乳类动物的神经系统内高度表达，而且在T细胞、肿瘤细胞和正常上皮细胞等非神经系统的细胞和组织中存在表达。在神经系统中，CRMP-2在促进神经轴突生长、维持神经细胞极性、神经元迁移等方面均起着重要作用。在非神经系统中，CRMP-2正向调节T细胞骨架重组和细胞迁移，负向调节肿瘤细胞的迁移水平，并以磷酸化形式参与肿瘤细胞增殖，被认为可能成为某些恶性肿瘤的生物标志物和治疗靶点。

    【关键词】脑衰反应调节蛋白-2；轴突生长;细胞迁移；肿瘤；子宫内膜异位症

    DOI：10.3969/g.issn.0253-9802.2015.03.002

    通讯作者，陈淑琴, E-mail:chenshuqin1021@163.com

    收稿日期：(2014-09-18)

    Study of CRMP-2 in cell migration and non-nervous system-related diseasesFanLi,ChenShuqin.DepartmentofObstetricsandGynecology,theFirstAffiliatedHospitalofSunYat-senUniversity,Guangzhou510080,China

    Correspondingauthor,ChenShuqin，E-mail:chenshuqin1021@163.com

    Abstract【】Collapsin response mediator protein-2(CRMP-2) is a multi-functional regulator protein. CRMP-2 is not only highly expressed in the mammalian nervous system, but also in non-neuronal cells and tissues, such as T lymphocytes, tumor cells and normal epithelial cells. In the nervous system, CRMP-2 plays an important role in promoting the outgrowth of neural axon, maintaining neural cell polarity and neuron migration. In the non-neuronal system, CRMP-2 positively regulates the cytoskeletal arrangement and cell migration of T lymphocytes, negatively interferes the cell migration of tumor cells and participates in tumor cell proliferation via phosphorylation. CRMP-2 is considered as a biomarker and therapeutic target of certain malignant tumors. ......