作者单位：330006 南昌，南昌大学第二附属医院消化内科

    Ki-67、P53和CyclinD1在小肠腺癌中的作用

    黄缘王素琴邹文雄李军王建强熊艳艳

    【摘要】目的探讨Ki-67、P53及CyclinD1在小肠腺癌中的表达情况及意义。方法采用SP法检测84例小肠腺癌标本中Ki-67、P53和CyclinD1在不同分化程度、年龄及性别的表达情况，与10例正常小肠组织进行对照，并进行统计学分析。结果Ki-67、P53和CyclinD1在正常组织中未表达，而在小肠腺癌的表达随肿瘤分化程度的降低而升高。高分化、中分化及低分化各组间比较都有明显差异(P0.05)。结论Ki-67、P53和CyclinD1在小肠腺癌的恶性程度判断方面有一定的指导意义。

    【关键词】Ki-67；P53；CyclinD1；小肠腺癌；免疫组织化学

    DOI:10.3969/g.issn.0253-9802.2015.05.007

    基金项目：江西省卫生厅科技计划(20063108)

    通讯作者，黄缘，E-mail： huangy9815@163.com

    收稿日期：(2014-12-17)

    The significance of Ki-67, P53 and CyclinD1 in small intestine adenocarcinomaHuangYuan,WangSuqin,ZouWenxiong,LiJun,WangJianqiang,XiongYanyan.DepartmentofGastrointestinalDisease,theSecondAffiliatedHospitalofNanchangUniversity,Nanchang330006,China

    Correspondingauthor，HuangYuan,E-mail:huangy9815@163.com

    Abstract【】ObjectiveTo investigate the expression levels and clinical significance of Ki-67, P53 and CyclinD1 in patients with small intestine adenocarcinoma. MethodsThe expression levels of Ki-67, P53 and CyclinD1 in tumor tissue from 84 small intestine adenocarcinoma patients with different degree of tumor differentiation, ages and gender were examined with SP, and normal intestinal tissues from 10 healthy individuals were used as control. ResultsKi-67, P53 and CyclinD1 were not expressed in normal small intestinal tissues, whereas the expression levels of Ki-67, P53 and CyclinD1 in small intestine adenocarcinoma samples were significantly elevated along with the declining degree of tumor differentiation with statistical significance among the high-, moderate- and low-differentiation groups(all P0.05). ConclusionKi-67, P53 and CyclinD1 may provide guidance for evaluating the malignancy of small intestine adenocarcinoma. ......