作者单位：510630 广州，南方医科大学第三附属医院检验科

    140株嗜麦芽窄食单胞菌的临床分布及耐药性分析

    尤旭孙恒彪黄敬张婧潘祖汉陈佑明

    【摘要】目的研究嗜麦芽窄食单胞菌的临床分布和耐药特点，为临床预防和治疗嗜麦芽窄食单胞菌感染及医院感染控制提供依据。方法采用微生物鉴定仪对2011至2014年分离到的140株嗜麦芽窄食单胞菌进行培养鉴定和药物敏感试验，并做临床常用抗生素耐药性分析，应用WHONET 5.5软件对数据进行统计学分析。结果140株嗜麦芽窄食单胞菌主要来源于呼吸道痰标本，占80.0%，主要分布于ICU(35.7%)、神经外科(12.9%)和呼吸内科(11.4%)。临床分离的嗜麦芽窄食单胞菌对常见抗生素的总耐药率为复方新诺明7.1%、左氧氟沙星24.3%、头孢他啶79.3%、替卡西林/克拉维酸71.4%。结论该院嗜麦芽窄食单胞菌感染者主要集中在ICU和神经外科，以呼吸道感染居多。对复方新诺明和左氧氟沙星有较高的敏感性，但对头孢他啶和替卡西林/克拉维酸耐药性较高。

    【关键词】嗜麦芽窄食单胞菌；临床分布；抗菌药物；耐药性

    DOI:10.3969/g.issn.0253-9802.2015.06.009

    通讯作者，陈佑明，E-mail:cym38432@163.com

    收稿日期：(2015-02-06)

    Analysis of clinical distribution and drug resistance of 140 Stennotrophomonas maltophilia strainsYouXu,SunHengbiao,HuangJing,ZhangJing,PangZuhan,ChenYouming.DepartmentofClinicalLaboratory,theThirdAffiliatedHospitalofSouthernMedicalUniversity,Guangzhou510630,China

    Correspondingauthor,ChenYouming，E-mail:cym38432@163.com

    Abstract【】ObjectiveTo investigate the clinical distribution and drug resistance characteristics of Stenotrophomonas maltophilia (S.maltophilia) strains, aiming to provide guidelines for the clinical prevention and treatment of S.maltophilia and control of nosocomial infection. MethodsA total of 140 S.maltophilia strains isolated from various clinical specimens from July 2011 to June 2014 were cultured, identified and tested for drug sensitivity by using Microscan microbial identification and subjected to antibiotic resistance analysis. The data analysis was performed by WHONET V5.5. ResultsApproximately 80.0% of S.maltophilia strains were detected from the respiratory tract phlegm samples, mainly distributed in intensive care unit (ICU) (35.7%), neurosurgery department (12.9%), and respiratory department (11.4%). The overall resistance rate of 140 isolated strains to compound sulfamethoxazole was 7.1%, 24.3% for levfloxacin, 79.3% for cephradine and 71.4% for ticarcillin/clavulanate. ConclusionsMost of the S. maltophilia were isolated from ICU and neurosurgery department in our hospital, dominantly from respiratory tract infection. S. maltophilia stains had relatively high sensitivity to compound sulfamethoxazole and levloxacin, and were relatively highly resistant to cephradine and ticarcillin/clavulanate. ......