术后认知功能障碍的研究进展

    吴祥高涛徐义国朱伟周东升姚琴张文武

    【摘要】术后认知功能障碍(POCD)是指由麻醉和(或)手术引起的学习和记忆能力、人格和社会行为能力下降。POCD的发病机制尚未十分明确，其会延长患者的康复时间,甚至增加患者病死率，至今尚无有效的防治手段。多数研究表明,老年患者较年轻患者有更高的POCD发病风险，人口老龄化也使POCD越来越受到学者们的重视。该文就POCD的诊断、危险因素、发病机制、治疗及预防等方面的研究进展作一介绍。

    【关键词】术后认知功能障碍；老年患者；发病机制；治疗

    收稿日期：(2015-04-30)

    DOI：10.3969/g.issn.0253-9802.2015.10.003

    通讯作者，林潮双，E-mail：shuangss@21cn.com

    Research progress on postoperative cognitive dysfunctionWuXiang,GaoTao,XuYiguo,ZhuWei,ZhouDongsheng,YaoQin,ZhangWenwu.TheAffiliatedHospitalofMedicalSchoolofNingboUniversity,Ningbo315020,China

    Abstract【】Postoperative cognitive dysfunction (POCD) refers to the declining ability of learning and memory, personality and social behavior caused by anesthesia and (or) surgery. The pathogenesis of POCD remains elusive. POCD prolongs the recovery time of patients and even increases the mortality rate. No effective treatment has been available yet. Most studies have indicated that POCD more commonly occurs in old adults than young counterparts. POCD has captured more and more interests from the physicians due to the aging issue. This review focused upon the research progress on the diagnosis, risk factors, pathogenesis, treatment and prevention of POCD. ......