妊娠期抗病毒治疗阻断HBV母婴传播的研究进展

    曾映夫林潮双

    【摘要】HBV感染是一个全球性的健康问题，全世界约有4亿人口为HBV携带者，中国约有1.2亿人口的HBsAg呈阳性，超过50%的病例是通过母婴垂直传播而感染，经垂直传播感染HBV的患者病情极易慢性化。研究证实，孕妇血清高病毒载量是HBV母婴垂直传播最重要的危险因素，与HBeAg阳性也有关联。妊娠期使用抗病毒药物使HBV DNA载量在分娩时达到最低，能明显降低HBV母婴垂直传播几率。在权衡药物对孕妇及胎儿利弊的前提下，可考虑在妊娠晚期给予孕妇抗病毒治疗。

    【关键词】乙型肝炎病毒;妊娠;母婴传播;抗病毒治疗

    收稿日期：(2015-04-22)

    DOI：10.3969/g.issn.0253-9802.2015.10.004

    Research progress of blocking mother-to-infant transmission of hepatitis B virus through antiviral therapy during pregnancyZengYingfu，LinChaoshuang.DepartmentofInfectiousDiseases,theThirdAffiliatedHospitalofSunYat-senUniversity,Guangzhou510630，China

    Correspondingauthor，LinChaoshuang，E-mail:shuangss@21cn.com

    Abstract【】Hepatitis B virus (HBV) infection is a global health problem with approximately 400 million carriers across the world. In China, nearly 120 million individuals are HBsAg positive. Over 50% of these carriers are infected vertically from their mothers, and vertically-acquired HBV infection is highly likely to become chronic. Previous studies have demonstrated that high viral load in pregnant woman is the most important risk factor of mother-to-infant transmission, which is also correlated with positive HBeAg. Administration of antiviral drugs during pregnancy can minimize the viral load before delivery remarkably reduce the risk of mother-to-infant transmission of HBV. After fully considering the advantages and disadvantages of antiviral agents to mother and fetus, antiviral therapy may be considered to the pregnant women during the late trimester. ......