于敏?刘志河?华兴?韦建瑞

    【摘要】动脉粥样硬化(AS)是严重危害人类生命健康的一類慢性血管疾病，局部胆固醇的大量蓄积和炎症的发生是其主要原因。现已证明许多细胞因子通过调节巨噬细胞向M1及M2型的转化，影响巨噬细胞对脂质的摄取及排出。该文将阐述干扰素调节因子5(IRF5)是否通过调节巨噬细胞的极化而对巨噬细胞的脂质摄取及排出产生影响，从而为以IRF5为作用靶点治疗AS的可能性提供一些前期理论研究。

    【关键词】动脉粥样硬化;干扰素调节因子5;巨噬细胞;极化;脂质

    IRF5 influences the uptake and excretion of lipid in macrophage through regulating macrophage polarization Yu Min， Liu Zhihe， Hua Xing， Wei Jianrui. School of Clinical Medicine， Guizhou Medical University， Guiyang 550004， China

    Corresponding author， Wei Jianrui， E-mail： jianruiw@ 163. com

    【Abstract】Atherosclerosis is a chronic vascular disease that seriously endangers the life and health of human. The accumulation of local cholesterol and the recurrence of inflammation are the major causes.Through the transformation to M1 and M2， macrophages play an important role in regulating the uptake and excretion of lipid.In this article ......