罗雪艳?李莉?关瀛?邓婷婷?秦坤

    【摘要】丙型肝炎病毒(HCV)感染导致的肝外损害以肾损伤多见，同时慢性肾脏病发展到终末期肾病行血液透析时可增加HCV感染风险。慢性丙型肝炎合并肾脏疾病可加速疾病的进程，造成患者的不良预后。该文对HCV致肾损伤的机制和慢性丙型肝炎合并肾脏疾病的直接抗病毒药物治疗等研究在近年所取得的进展进行综述，旨在加深临床医师对慢性丙型肝炎合并肾脏疾病患者行抗病毒治疗的认识，改善患者预后。

    【关键词】慢性丙型肝炎;抗病毒治疗;慢性肾脏病;血液透析;腹膜透析;直接抗病毒药物

    Research progress on antiviral therapy for hepatitis C complicated with renal diseaseLuo Xueyan， Li Li， Guan Ying， Deng Tingting， Qin Kun. Zunyi Medical University， Zunyi 563099， China

    Corresponding author， Li Li， E-mail： 1444522659@ qq. com

    【Abstract】Kidney disease is the most common event among extrahepatic injuries caused by hepatitis C virus (HCV) infection. Meantime， the risk of HCV infection can be increased when chronic renal disease progresses into the end-stage renal disease requiring hemodialysis. Chronic hepatitis C (CHC) complicated with kidney disease can accelerate the progression of disease， leading to poor clinical prognosis. In this article， research progresses on the mechanism of renal disease caused by HCV and direct antiviral treatment for patients with chronic kidney disease complicated with CHC were reviewed ......