李伟浩?张韬?张学民?李伟?李清乐?焦洋?徐海林

    【摘要】目的 探討通塞脉片在糖尿病下肢动脉闭塞患者接受下肢动脉介入术后的治疗效果。方法 收集78例糖尿病下肢动脉闭塞严重肢体缺血患者的临床资料，根据患者术后是否服用通塞脉片分为观察组和对照组，对照组介入术后接受抗血小板药物治疗，观察组在抗血小板药物基础上加用通塞脉片。比较2组临床治疗效果。结果 总体手术成功率94%，观察组和对照组的手术成功率、补救性支架植入率、开通的膝下动脉支数比较差异均无统计学意义(P均> 0.05)。随访6个月时，观察组2例(5%)患者分别死于心肌梗死和脑梗死，对照组1例(3%)患者死于心肌梗死。观察组和对照组的总体保肢率分别为81%和67%，临床症状驱动的靶血管再血管化率分别为17%和14%。2组患者总体保肢率、再血管化率和全因死亡率比较差异均无统计学意义(P均> 0.05)。观察组患者小截肢率低于对照组(14% vs. 33%，P 0.05). At the follow-up at 6 months after surgery， two patients (5%) in the observation group died of myocardial infarction and cerebral infarction， and one patient (3%)in the control group died of myocardial infarction. The overall limb salvage rates in the observation and control groups were 81% and 67%， and the revascularization rates of target vessels driven by clinical symptoms were 17% and 14%. The overall limb salvage rate， revascularization rate and all-cause mortality did not significantly differ between two groups (all P > 0.05). However ......