刘秋霞?孙彩萍?叶万立?徐俊?朱晓灵?刘建江?孙红岗?王建芳

    【摘要】目的 探討炎症因子与乳腺癌患者辅助放射治疗期间癌性疲劳的相关性。方法 选取术后辅助放射治疗的乳腺癌患者，按埃德蒙顿症状评估系统的疲劳评分将其分为疲劳组及观察组，比较2组血清炎症因子CRP、IL-6及可溶性肿瘤坏死因子受体2(sTNFR2)的差异;检测每位患者的疲劳相关炎症因子编码基因启动子的单核苷酸多态性，分析炎症因子相关基因分型与放射治疗结束时疲劳评分的相关性。结果 共61例患者入组，其中疲劳组37例。观察组24例，癌性疲劳的发生率为60.6%。疲劳组伴有恶心、焦虑及厌食者较观察组多(P均 0.05)。IL-6水平与疲劳的发生呈正相关(rs = 0.51，P 0.05)。IL-6启动子编码基因IL6-174 GG基因分型的乳腺癌患者放射治疗结束时的疲劳评分高于CC基因分型患者(P = 0.001)。结论 血清IL-6水平及IL6-174 GG基因分型或与乳腺癌辅助放射治疗期间癌性疲劳的产生有关。

    【关键词】炎症因子;癌性疲劳;白介素-6;IL6-174基因;乳腺癌

    Correlation between inflammatory cytokines and cancer-related fatigue in breast cancer patients undergoing adjuvant radiotherapy Liu Qiuxia， Sun Caiping， Ye Wanli， Xu Jun， Zhu Xiaoling， Liu Jianjiang， Sun Honggang， Wang Jianfang. Shaoxing Peoples Hospital (Shaoxing Hospital of Zhejiang University)， Shao- xing 312000， China

    Corresponding author， Wang Jianfang， E-mail： sxwxdd@ 163. com

    【Abstract】Objective To investigate the correlation between inflammatory cytokines and cancer-related fatigue (CRF) in breast cancer patients undergoing adjuvant radiotherapy. Methods Breast cancer patients receiving postoperative adjuvant radiotherapy were recruited and divided into the fatigue group and observation group according to the fatigue score of Edmonton Symptom Assessment System. The differences of serum inflammatory cytokines of CRP ......