易观容 周宇

    【摘要】长链非编码RNA(lncRNA)TNF-α和异质性胞核核糖核蛋白L(hnRNPL)相关的免疫调节lncRNA(THRIL)与hnRNPL结合形成功能性THRIL-hnRNPL复合物，结合在TNF-α的启动子上进而调节TNF-α的表达。研究表明THRIL可能通过调节TNF-α的表达参与多种炎症性疾病、肿瘤和其他疾病的发生与进展，THRIL可能成为疾病药物治疗的新靶点。该文主要综述THRIL在多种疾病中的表达水平和可能的调节机制。

    【关键词】长链非编码核糖核酸;免疫反应;炎症性疾病;TNF-α和异源性核核糖核蛋白L相关的免疫调节长链非编码核糖核酸

    Research progress on the relationship between LncRNA THRIL and diseases Yi Guanrong， Zhou Yu. Department of Gastroenterology， Affiliated Hospital of Guangdong Medical University， Zhanjiang 524000， China

    Corresponding author， Zhou Yu， E-mail： ahdg2005@ 126. com

    【Abstract】 The long noncoding RNA (lncRNA) TNF-α and heterogenous nuclear ribonucleoprotein L (hnRNPL)-related immunoregulatory long noncoding RNA (THRIL) bind with hnRNPL to form functional THRIL-hnRNPL complex at the TNF-α promoter， which can regulate the expression of TNF-α. Studies have demonstrated that THRIL participates in the incidence and progression of inflammatory diseases， tumors and other diseases probably by regulating the expression of TNF-α. Therefore ......