蒋慧云?黄珊瑜?李小毛

    【摘要】目的 探究卵巢畸胎瘤患者中發生抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎的比例，并将合并抗NMDAR脑炎的卵巢畸胎瘤患者与未合并抗NMDAR脑炎的卵巢畸胎瘤患者的临床特征进行总结对比。方法 收集卵巢畸胎瘤患者的临床资料，将其分为合并抗NMDAR脑炎组与未合并抗NMDAR脑炎组，对其临床特征进行对比分析。结果 共收集到168例卵巢畸胎瘤患者，其中14例(8.3%)合并抗NMDAR脑炎;合并抗NMDAR脑炎的卵巢畸胎瘤患者年龄低于未合并抗NMDAR脑炎的卵巢畸胎瘤患者[(23.8±5.5)岁 vs. (29.8±9.1)岁，P = 0.016]。合并抗NMDAR脑炎的卵巢畸胎瘤患者肿瘤标志物以癌抗原125及血清铁蛋白升高为主，而未合并抗NMDAR脑炎的卵巢畸胎瘤患者肿瘤标志物以糖类抗原199升高为主。合并抗NMDAR脑炎与未合并抗NMDAR脑炎的卵巢畸胎瘤患者的肿瘤组织均可含有神经组织。结论 卵巢畸胎瘤患者中发生抗NDMAR脑炎的比例不低，对于无明显症状的卵巢畸胎瘤患者，可考虑积极行手术治疗，以降低发生抗NMDAR脑炎的风险。

    【关键词】卵巢畸胎瘤;抗N-甲基-D-天冬氨酸受体脑炎;神经系统副肿瘤综合征;癌抗原125;血清铁蛋白;糖类抗原199

    Proportion and clinical features of anti-N-methyl-D-aspartate receptor encephalitis in patients with ovarian teratoma in a single center Jiang Huiyun， Huang Shanyu， Li Xiaomao. Department of Gynecology， the Third Affiliated Hospital of Sun Yat-sen University， Guangzhou 510630， China Corresponding author， Li Xiaomao， E-mail： lixmao@ mail. sysu. edu. cn

    【Abstract】Objective To determine the incidence of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in patients with ovarian teratoma and to compare the clinical characteristics between ovarian teratoma patients with and without anti-NMDAR encephalitis. Methods Clinical data of ovarian teratoma patients were collected and divided into the anti-NMDAR encephalitis group and non-anti-NMDAR encephalitis group. Clinical characteristics were statistically compared between two groups. Results Among 168 patients with ovarian teratoma ......