严美茹 张燕平 罗瑞琦 王思媛

    【摘要】 磷脂酰激醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路作为经典的细胞信号转导途径，在细胞生长、增殖、分化和凋亡等多种生物学过程中发挥作用。脑出血是一种高致残率和高致死率的脑血管疾病，该通路在脑出血发生发展中的研究也备受关注。该文以PI3K/Akt信号通路为主线，对该通路的结构及生物学特点、与脑出血之间的关系以及基于该通路探讨药物对脑出血的作用进行综述，为临床脑出血的治疗提供新的思路。

    【关键词】 脑出血;PI3K/Akt信号通路;细胞凋亡;神经炎症

    【Abstract】 As a classic cell signal transduction pathway， PI3K/Akt pathway plays a role in a variety of biological processes， such as cell growth， proliferation， differentiation and apoptosis. As a kind of cerebrovascular disease with high disability and high mortality， the role of this signaling pathway in the incidence and development of cerebral hemorrhage has attracted more and more attention. In this article， the PI3K/Akt signal pathway was regarded as the main topic to analyze the structural and biological characteristics of this pathway， its relationship with cerebral hemorrhage and review the efficacy of drugs for cerebral hemorrhage based on the PI3K/Akt signaling pathway， aiming to provide novel ideas for the clinical treatment of cerebral hemorrhage.

    【Key words】 Cerebral hemorrhage; PI3K/Akt signal pathway; Cell apoptosis; Neuroinflammation ......