吴佳敏 张炜 张兴 陈麒

    【摘要】 特发性肺纤维化(IPF)是一种慢性进行性的间质性肺病，其发病机制目前尚无定论。成纤维细胞直接参与IPF过程的理论已被广泛接受，同时研究认为IPF的形成、发展与炎症、免疫息息相关，主要表现为免疫细胞与成纤维细胞间的相互作用。外泌体是细胞间进行生物信息通信的重要载体，不同细胞来源的外泌体携带着不同的信号因子，可作为免疫细胞与成纤维细胞的桥梁，在IPF的炎症反应和免疫调节中发挥作用，同时外泌体或将成为临床诊断和治疗IPF的重要方法。该文就不同细胞来源的外泌体在IPF中的研究进展进行综述，以了解外泌体作为细胞间信息交流的载体在调节IPF的形成与发展中的作用。

    【关键词】 特发性肺纤维化;外泌体;炎症;免疫;成纤维细胞;间质性肺炎

    【Abstract】 Idiopathic pulmonary fibrosis (IPF) is a chronic progressive interstitial lung disease. The pathogenesis of IPF remains elusive. The theory that fibroblasts directly participate in the IPF process has been widely accepted. Moreover， studies have demonstrated that the incidence and development of IPF is intimately related to inflammatory and immunity， which is mainly manifested with the interaction between immune cells and fibroblasts. Exosomes are important carriers for biological information communication between cells， and exosomes from different cell sources can carry different signal factors， which serve a bridge between immune cells and fibroblasts ......