金嘉成?王锐?王士铭?蓝兰?王建伯

    【摘要】近几十年来，肿瘤微环境(TME)作为肿瘤发生、发展、免疫逃避和治疗反应的关键而成为肿瘤研究的热点。而作为肿瘤微环境中的物理特性，“固相应力”可由周围正常组织从肿瘤外部施加产生，也可由肿瘤本身生长而引起。随着肿瘤的生长，固相应力会通过生化-物理机制破坏周围组织的结构和功能，并促进肿瘤的发生和肿瘤治疗的抗性。该文针对固相应力在肿瘤中的发生机制及相关进展进行综述，探讨恶性肿瘤生物学和物理学之间的联系，为新型药物研发和肿瘤治疗策略制定提供参考。

    【关键词】固相应力；肿瘤微环境；生物力学；力学刺激；力学信号转导

    Research progress on solid stress in tumors Jin Jiacheng， Wang Rui， Wang Shiming， Lan Lan， Wang Jianbo. Department of Urology， the First Affiliated Hospital of Dalian Medical University， Dalian 116011， China

    Corresponding author， Wang Jianbo， E-mail： wangjianbo@dlmedu.edu.cn

    【Abstract】In recent decades， tumor microenvironment (TME) plays a significant role in tumorigenesis， progression， immune evasion， and therapeutic response， which has become a hot topic in tumor research. As a physical feature of TME， “solid stress” can be applied from the outside by surrounding normal tissues or caused by the tumor itself due to its growth. As the tumor grows， solid stress will destroy the structure and function of surrounding tissues through biochemical-physical mechanisms and promote tumor occurrence and treatment resistance. In this article ......