沈月英?王楠?张玥

    【摘要】心肌收缩力调节器(CCM)是应用于心力衰竭患者的一种新的治疗方法，其通过调节心肌细胞中钙离子的浓度以及调节自主神经功能来增强心肌收缩力，从而改善心力衰竭患者的症状、运动耐受性、生活质量、心肌收缩力以及心室重塑，并且不增加心肌耗氧量，CCM尤其适用于LVEF为35%～45%的患者。CCM的广泛应用可以给心力衰竭患者带来新的希望。该文对CCM的作用机制、适用人群、临床疗效及安全性进行综述，以期为临床医师提供参考。

    【关键词】心肌收缩力调节器；心力衰竭；钙离子；心脏辅助装置；心脏再同步治疗

    Cardiac contractility modulator： new hope for heart failure patients Shen Yueying△， Wang Nan， Zhang Yue. △First Clinical Medical School， Gansu University of Traditional Chinese Medicine， Lanzhou 730000， China

    Corresponding author， Wang Nan， E-mail： wangnan2015@163.com

    【Abstract】 Cardiac contractility modulation (CCM) is a novel treatment method for patients with heart failure. It can enhance myocardial contractility by regulating the concentration of calcium ions in cardiomyocytes and modulating autonomic nerve function， thereby mitigating relevant symptoms， improving exercise tolerance， quality of life， myocardial contractility and ventricular remodeling in patients with heart failure， whereas it does not increase myocardial oxygen consumption. CCM is especially suitable for patients with a left ventricular ejection fraction of 35%-45%. Widespread application of CCM can bring new hope to patients with heart failure. In this article ......