罗成 吴聪 王玉光

    【摘要】 结节病是以非干酪性上皮样细胞肉芽肿为特征的全身性疾病，可累及多个器官，以肺为多见。结节病临床表现多样，发病率高，其中部分肺结节病患者可自发缓解，但停药后极易复发，部分纤维化型肺结节病患者病情持续进展，预后不良。因此管理决策重要且具有挑战性。目前关于结节病的治疗虽已达成初步共识，但仍需要进一步细化。同时，随着药物的不断开发，部分生物制剂已能有效治疗结节病。该文探讨结节病目前的药物治疗进展，其中糖皮质激素及免疫抑制剂可能是治疗结节病的关键，生物制剂是未来研究的热点。

    【关键词】 结节病；糖皮质激素；生物制剂；抗纤维化治疗

    Research progress on drug treament for sarcoidosis Luo Cheng△， Wu Cong， Wang Yuguang.△Beijing Hospital of Traditional Chinese Medicine affiliated to Capital Medical University， Beijing 100010， China

    Corresponding author， Wang Yuguang， E-mail： wygbjzyyy@126.com

    【Abstract】 Sarcoidosis is a systemic disease characterized by non-caseous epithelioid cell granuloma， which can involve with multiple organs， especially the lung. Sarcoidosis is characterized by diverse clinical manifestations and high incidence rate. Partial patients with pulmonary sarcoidosis can spontaneously relieve， whereas it is likely to recur after drug withdrawal. Some patients with fibrotic sarcoidosis persistently progress and obtain poor prognosis. Therefore， how to deliver clinical treatment is highly important and challenging. At present ......