田梦昕?赵义

    【摘要】痛风在男性和绝经后女性中的发病率升高提示痛风与性别密切相关，且受体内性激素的影响。然而，性激素是如何参与痛风发病的，二者真正的关系如何目前并不十分清楚。该文结合近年来痛风研究的相关进展，对性激素在痛风发病中的作用机制进行综述。

    【关键词】痛风；性激素；雌激素；雄激素；发病机制

    Advances in the study of the role of sex hormones in the pathogenesis of gout Tian Mengxin， Zhao Yi. Department of Rheumatology and Immunology， Xuanwu Hospital， Capital Medical University， Beijing 100053， China

    Corresponding author， Zhao Yi， E-mail： zy85070@xwhosp.org

    【Abstract】The increased incidence of gout in men and postmenopausal women suggests that gout is closely associated with sex and affected by sex hormones. However， how sex hormones are involved in the onset of gout and the exact relationship between these two are poorly understood. In this article， recent advances in the study of gout were summarized， and the mechanism underlying the role of sex hormones in the pathogenesis of gout was reviewed.

    【Key words】Gout； Sex hormone； Estrogen； Androgen； Pathogenesis

    流行病学研究显示，痛风的总体发病率和患病率呈增长趋势：2017年全球年龄标准化患病率和发病率分别相比1990年增加了7.2%，其中我国1990—2019年间痛风患病人数增长了175.6%，发病人数增加了157.31%[1-2]。痛风发病存在明显的性别差异，美国痛风患者中男女比例约为3∶1 ......