吴霞?梁亮

    【摘要】 随着纳米纤维在各行各业的广泛应用，静电纺丝作为一种制备纳米纤维的技术也得到了关注。静电纺丝制备的纳米纤维膜由于与细胞外基质相似，具有高比表面积、高孔隙率、易添加多种成分等特点，使其在药物装载上具有很大的优势，已有研究将药物负载在纳米纤维中从而实现药物缓释作用。目前静电纺丝膜已经应用于眼表疾病、角膜移植、青光眼及视网膜疾病治疗等，本文将在目前已有基础上，介绍静电纺丝技术的原理、应用及展望静电纺丝技术在眼科疾病治疗的前景。

    【关键词】 静电纺丝； 载药； 眼表疾病； 青光眼； 角膜移植； 视网膜； 纳米纤维

    Progress in application of electrospinning technology in ophthalmology Wu Xia， Liang Liang. The First College of Clinical Medical Science， China Three Gorges University； Department of Ophthalmology， Yichang Central People’ s Hospital； Institute of Ophthalmology and Visual Science， China Three Gorges University， Yichang 443003， China

    Corresponding author， Liang Liang， E-mail： liangliang419519@163.com

    【Abstract】 With widespread application of nanofibers in various industries， electrospinning， as a technology for preparing nanofibers， has also received attention. The nanofiber membrane prepared by electrospinning has excellent advantages in drug loading due to its high specific surface area， high porosity， and easy addition of various components， similar to the extracellular matrix. In current studies ......