张春洋?陈付群?陈兆云

    【摘要】肝纤维化是各种慢性肝脏病向肝硬化发展过程中的关键，是肝中多类细胞、细胞因子及介质共同作用的结果，肝星状细胞(HSC)在肝纤维化阶段充当重要角色。维生素D是以1，25-二羟维生素D3为活性形式，与慢性肝病严重程度密切相关的甾体激素，在HSC的调控中占据关键地位。维生素D可通过转化生长因子-β/SMAD、Wnt/β-catenin、ERK1/2、多蛋白细胞质复合体NOD样受体家族3、核因子-κB等多种细胞信号通路调节相关靶基因表达，抑制HSC活化，进而控制肝纤维化进展。该文就维生素D与HSC的关系、维生素D在肝纤维化中调控HSC的机制及在抗纤维化治疗中相关研究进展做一综述。

    【关键词】维生素D；肝星状细胞；肝纤维化；通路

    Research progress in effect of vitamin D on inhibiting hepatic stellate cell activation in liver fibrosis Zhang Chunyang， Chen Fuqun，Chen Zhaoyun. Medical Laboratory Center， the First Affiliated Hospital of Xinjiang Medical University， Urumqi 830054， China

    Corresponding author， Chen Zhaoyun，E-mail： czy52010710@163.com

    【Abstract】Liver fibrosis is a key factor in the progression from various chronic liver diseases to cirrhosis， which is the result of the combined action of multiple types of cells， cytokines， and mediators in the liver. Hepatic stellate cells (HSCs) play an important role in the stage of liver fibrosis. Vitamin D with 1，25-dihydroxy vitamin D3 as the active form， has been found to be a steroid hormone closely associated with the severity of chronic liver disease ......