李向庚?高媛?孙淑艳

    【摘要】糖尿病心肌病(DCM)是指单纯由高血糖引起的心肌细胞或心脏微血管损伤及代谢障碍。有研究表明，DCM与线粒体融合异常密切相关。视神经萎缩蛋白1(Opa1)是线粒体融合的主要蛋白之一。在高血糖环境下，Opa1表达减少，造成线粒体融合障碍，进而引起心肌细胞能量代谢障碍、氧化应激、胰岛素抵抗与脂毒性增加、细胞凋亡等，最终导致DCM。上调Opa1的表达则能使DCM的症状得到改善。该文就Opa1与DCM的相关性的研究进展做一综述，为DCM的研究提供新思路。

    【关键词】视神经萎缩蛋白1；线粒体融合；糖尿病心肌病；心肌细胞；发病机制；能量代谢障碍；氧化应激；

    胰岛素抵抗与脂毒性；细胞凋亡

    Research progress on the association between Opa1 and diabetic cardiomyopathy Li Xianggeng△， Gao Yuan， Sun Shuyan.

    △The Graduate School of Baotou Medical College of Inner Mongolia University of Science and Technology， Baotou 014000， China

    Corresponding author， Sun Shuyan， E-mail： 13634729978@163.com

    【Abstract】Diabetic cardiomyopathy (DCM) refers to myocardial cell or cardiac microvascular injury and metabolic disorder caused by hyperglycemia alone. Studies have shown that DCM is closely associated with abnormal mitochondrial fusion. Optic atrophy 1 (Opa1) is one of the main proteins of mitochondrial fusion. Under hyperglycemia environment， the expression level of Opa1-1 is down-regulated， resulting in mitochondrial fusion disorder， which thereby leads to energy metabolism disorder ......