齐梅?周悦?张梦圆?方盛泉

    【摘要】胃食管反流病(GERD)是临床常见的一种治疗具有挑战性的反复发作性疾病。长期烧心和(或)反流症状严重影响患者日常生活质量。研究表明，GERD与食管抗反流屏障受损密切相关，黏蛋白(MUC)即为该屏障主要组成成分。该文主要对MUC在GERD发病机制中的作用及其影响因素作一综述。

    【关键词】黏蛋白；胃食管反流；发病机制；影响因素

    Research progress on the role of mucin in the pathogenesis of gastroesophageal reflux disease Qi Mei，Zhou Yue， Zhang Mengyuan， Fang Shengquan. Department of Gastroenterology， Yueyang Hospital of Integrative Medicine， Shanghai University of Traditional Chinese Medicine， Shanghai 200080， China

    Corresponding author， Fang Shengquan， E-mail： fsq20032003@163.com

    【Abstract】Gastroesophageal reflux disease (GERD) is a common recurrent disease and the treatment of GERD is challenging. Chronic heartburn and/or reflux symptoms seriously affect the quality of daily life of patients. Studies have shown that GERD is closely associated with the impairment of anti-reflux barrier of the esophagus， of which mucin (MUC) is the main component. The role of MUC in the pathogenesis of GERD and influencing factors were reviewed in this article.

    【Key words】Mucin； Gastroesophageal reflux； Pathogenesis； Influencing factor ......