王云 向晶晶 郑倩 柏金秀

    基金项目：河北大学附属医院基金(2022QC80)

    作者单位：071000? ?保定，河北大学附属医院儿科

    通信作者：柏金秀，E-mail： baijinx@163.com

    【摘要】抽动障碍是一种常见于儿童的神经发育障碍性疾病，患病率高，患者个体间临床表现差异大，常常合并其他神经精神疾病，给患者心理和生理健康带来极大的负担。抽动障碍的病因尚未明确，可能与遗传、免疫、环境及心理等多种因素有关，病理机制涉及皮质-纹状体-丘脑-皮质通路障碍及多巴胺的异常。铁在神经系统发育过程中具有重要的生物学功能。研究显示，铁缺乏可能引起大脑发育障碍、多巴胺功能受损进而导致抽动障碍的发生发展。改善机体铁营养状况、对抽动障碍患儿适当补充铁剂可能是防治抽动障碍的新思路。

    【关键词】铁缺乏；抽动障碍；图雷特综合征；发病机制；铁剂补充

    Research progress in the relationship between iron deficiency and tic disorder Wang Yun， Xiang Jingjing， Zheng Qian， Bai Jinxiu. Department of Pediatrics， Affiliated Hospital of Hebei University， Baoding 071000， China

    Corresponding author： Bai Jinxiu， E-mail： baijinx@163.com

    【Abstract】Tic disorder is a common neurodevelopmental disorder disease in children， with a high prevalence and different clinical manifestations among individuals. It is frequently complicated with other neuropsychiatric diseases， which brings significant burden to psychological and physical health of patients. At present， the etiology of tic disorder remains unclear， which is probably associated with genetic ......