李寒童 李悦凡 周妍 王琳

    【摘要】铁死亡抑制蛋白1(FSP1)是铁死亡过程中的关键抑制因子，能够阻止细胞死亡，具有重要的生物学功能和潜在的临床应用价值。本研究详细探讨了FSP1的发现背景、基因定位与结构特性，以及其在抑制铁死亡和促进细胞凋亡中的双重作用。临床研究已经开发出针对FSP1的抑制剂，如铁死亡抑制蛋白1抑制剂(iFSP1)和相分离诱导型铁死亡抑制蛋白1抑制剂(icFSP1)，未来的研究将进一步探讨FSP1的表达调控机制、与肿瘤免疫逃逸的关联以及其作为肿瘤预后和治疗反应监测指标的潜力。

    【关键词】铁死亡；铁死亡抑制蛋白1；肿瘤；铁死亡抑制蛋白1抑制剂；相分离诱导型铁死亡抑制蛋白1抑制剂

    The role of ferroptosis suppressor protein 1 in tumors

    LI Hantong， LI Yuefan， ZHOU Yan， WANG Lin

    (School of Stomatology， Xian Medical University， Xian 710075， China)

    Corresponding author： WANG Lin， E-mail： wanglin@xiyi.edu.cn

    【Abstract】Ferroptosis suppressor protein 1 (FSP1) is a key suppressor in the process of ferroptosis， which can prevent cell death and has important biological functions and potential value in clinical application. In this article， the discovery background， gene localization and structural characteristics of FSP1， as well as its dual role in inhibiting ferroptosis and promoting apoptosis were explicitly discussed. In clinical researches， FSP1 inhibitors， such as iFSP1 and icFSP1， have been developed. Subsequently， the regulatory mechanisms of FSP1 expression ......