【摘要】 随着新生儿重症监护技术日趋成熟，早产儿的存活率显著提高。然而，脑损伤的发生率亦在逐年上升，且多数患儿伴有神经系统损伤的早期临床表现和远期后遗症状。因此，寻找简单有效的诊断方法，提高早产儿生存质量，已成为当前领域亟待解决的关键问题。近年来，越来越多的生物学标志物被众多学者相继研究，并应用于早产儿脑损伤的早期诊断及预后评估，文章就这些生物学标志物的国内外研究进展进行综述，旨在为早产儿脑损伤的早期诊断和预后评估提供参考。

    【关键词】 生物学标志物；脑损伤；早产儿；细胞因子

    Research progress in biological markers for predicting brain injury in premature infants

    SHI Qunfang， WANG Yu

    (Department of Pediatrics， Hebei University Affiliated Hospital， Baoding 071000， China)

    Corresponding author： WANG Yu， E-mail： 13785269178@163.com

    【Abstract】 With the increasing maturity of neonatal intensive care technology， the survival rate of premature infants has been increased significantly. At the same time， the incidence of brain injury has also been elevated year by year， and most of the affected children are complicated with early clinical manifestations and long-term sequelae of nervous system injury. Therefore， finding a simple and effective diagnostic method to improve the quality of life of premature infants has become a key problem to be solved urgently in the current field. In recent years ......