【摘要】 支气管哮喘是由多种炎症细胞及细胞因子参与的气道慢性炎症性疾病。重度哮喘表现为反复发作、迁延不愈，咳嗽、胸闷、气短、喘憋等症状较难缓解，对患者的生活质量造成重大的影响。目前标准治疗为吸入大剂量皮质类固醇联合长效支气管舒张剂，但仍有部分患者哮喘症状不能得到充分控制，往往与持续性2型炎症有关。对于持续性2型炎症的重度哮喘患者，可选择使用生物靶向药物治疗。生物靶向药物治疗可显著改善症状，降低急性加重频率，减少口服糖皮质激素的使用，为2型炎症型重度哮喘患者带来了新的希望，在此文章对2型炎症型支气管哮喘的生物靶向治疗进行综述。

    【关键词】 支气管哮喘；2型炎症；生物靶向治疗

    Biological targeted therapy for type 2 inflammation bronchial asthma

    ZHANG Mingqiang， MU Xiangdong

    (Department of Pulmonary and Critical Care Medicine，Beijing Tsinghua Changgung Hospital， School of Clinical Medicine， Tsinghua University， Beijing 102218， China)

    Corresponding author： MU Xiangdong， E-mail： mxda02600@btch.edu.cn

    【Abstract】 Bronchial asthma is a chronic inflammatory disease of the airway involving multiple inflammatory cells and cytokines. Severe asthma is characterized by recurrent attacks and persistent symptoms such as coughing， chest tightness， shortness of breath， and wheezing， etc.， which are difficult to be alleviated and have a significant impact on the quality of life of patients. At present， the standard therapy of combining high-dose inhaled corticosteroids and long-acting bronchodilators is recommended ......