【摘要】 1型糖尿病(type 1 diabetes mellitus，T1DM)的发病率在全球呈上升趋势，环境因素在T1DM的发生和发展中扮演重要角色。已有研究表明，肠道菌群紊乱可能通过改变肠道通透性、改变菌群代谢产物丰度及调节免疫等机制引起T1DM。胰岛素仍然是目前主要的治疗手段，以肠道菌群为靶点干预T1DM成为当下的研究热点。文章综述了肠道菌群与T1DM的关系，讨论了益生菌对T1DM的防治作用及其机制，旨在为T1DM的防治研究拓宽思路。

    【关键词】 1型糖尿病；肠道菌群；益生菌；预防；治疗

    Research on the prevention and treatment of type 1 diabetes based on the mechanism of gut microbiota

    LI Ying， XU Ping， XUE Meng， LIANG Zhen ， WANG Jiasen

    (The Second Clinical Medical College， Jinan University， Shenzhen 518020， China)

    Corresponding author： LIANG Zhen， E-mail： liang.zhen@szhospital.com

    【Abstract】 The incidence of type 1 diabetes mellitus (T1DM) is increasing globally， with environmental factors playing a significant role in its onset and progression. Studies have shown that gut microbiota dysbiosis may lead to T1DM through mechanisms such as altering intestinal permeability， modifying the abundance of microbial metabolites， and regulating immune responses. While insulin remains the primary therapeutic means， targeting the gut microbiota has emerged as a promising research focus for T1DM intervention. This article reviews the relationship between gut microbiota and T1DM ......