【摘要】 子宫内膜癌(EC)是一种常见的妇科恶性肿瘤，预后相对较好，但其表观遗传致癌机制和治疗方案的进展仍有待探索。近年来越来越多的研究显示，腺瘤性息肉病大肠杆菌(APC)基因可作为有前景的诊断和治疗生物标志物。APC是典型的染色质重塑相关抑癌基因，其突变和功能异常已被报道与多种EC的发生与治疗耐药性有关。EC的发病机制可能涉及Wnt通路(生物体内一种调节器官发生、胚胎发育、组织稳态和肿瘤发生的细胞信号通路)异常、环境因素、遗传异常、高雌激素水平、异常错配修复以及DNA和微RNA的异常表达，基于其致癌机制选择相应的治疗策略可能有助于提高EC治疗的效果，文章主要综述了APC在早期EC癌变中的作用，并总结了其在EC治疗中的意义，为相关研究提供新的视角。

    【关键词】 APC基因；子宫内膜癌；Wnt通路；癌变机制

    The role of adenomatous polyposis coli gene in carcinogenesis and treatment of early-stage

    endometrial cancer

    WU Qiang1， LI Wenle2

    (1.The First Clinical School of Guangdong Medical University， Zhanjiang 524000， China； 2. Department of Obstetrics and Gynecology， Guangdong Medical University Affiliated Hospital， Zhanjiang 524000， China)

    Corresponding author： LI Wenle， E-mail： safety11@foxmail.com

    【Abstract】 Endometrial cancer (EC) is a common gynecological malignant tumor with relatively good prognosis. However， the progress in its epigenetic carcinogenic mechanisms and treatment regimens remains to be explored. In recent years， more and more studies have shown that the adenomatous polyposis coli (APC) gene can serve as a promising diagnostic and therapeutic biomarker. APC is a typical tumor-suppressor gene related to chromatin remodeling. Its mutations and functional abnormalities have been reported to be associated with the occurrence and therapeutic drug resistance of various types of EC. The carcinogenic mechanisms of EC may involve abnormalities in the Wnt pathway (a cell signaling pathway in organisms that regulates organogenesis ......