吸烟和细胞色素P450 1A1-MspⅠ、谷胱甘肽硫转移酶T1基因多态性与口腔癌的相关性研究(2)

http://www.100md.com 2012年2月1日 郭李柯 张超贤 史淑敏 郭晓凤

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     in oral cancer and control groups was 30.67% and 6.67% respectively(P<0.01). The people who carried with CYP1A1-

    MspⅠ(m2/m2)/GSTT1(-) had a high risk of oral cancer(OR=8.27, 95%CI 3.63-11.29). The smoking rate of the case group was significantly higher than that in the control group(OR=2.71, 95%CI 1.31-4.52, P<0.01), and statistic analy-

    sis suggested an interaction between smoking and CYP1A1-MspⅠ(m2/m2)/GSTT1(-) genotypes polymorphisms which

    increased risk of oral cancer(OR=25.00, 95%CI 11.87-

    35.64). Conclusion CYP1A1-MspⅠ(m2/m2) and GS-

    TT1(-) are the risk factors in oral cancer ......

    http://www.100md.com/html/paper/1000-1182/2012/02/19-1.htm

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