曹辉，许钟，张玲玲，白班俊(贵州省人民医院，贵阳550002)

    参芪扶正注射液辅助TACE治疗原发性肝癌的Meta分析Δ

    曹辉*，许钟，张玲玲，白班俊#(贵州省人民医院，贵阳550002)

    目的：系统评价参芪扶正注射液辅助肝动脉栓塞化疗(TACE)用于原发性肝癌的有效性和安全性，为临床提供循证参考。方法：计算机检索中国期刊全文数据库、万方数据库、中文科技期刊数据库和PubMed，纳入参芪扶正注射液联合TACE(试验组)对比单纯TACE(对照组)治疗原发性肝癌的随机对照试验(RCT)，提取资料并应用改良Jadad量表评价纳入研究质量后，采用Stata 12.0统计软件进行Meta分析。结果：共纳入8项RCT，合计527例患者。Meta分析结果显示，两组患者治疗有效率[RR＝1.19，95%CI(0.97，1.46)，P＝0.091]、临床受益率[RR＝1.16，95%CI(0.90，1.48)，P＝0.251]比较，差异均无统计学意义；试验组患者生存质量改善率显著高于对照组[RR＝2.26，95%CI(1.64，3.10)，P＝0.001]，中度以上发热发生率[RR＝0.74，95%CI(0.63，0.88)，P＝0.001]、胃肠道反应发生率[RR＝0.52，95%CI(0.32，0.85)，P＝0.010]和白细胞减少发生率[RR＝0.75，95%CI(0.62，0.92)，P＝0.005]均显著低于对照组，差异均有统计学意义。结论：参芪扶正注射液用于原发性肝癌TACE的辅助治疗不能提高患者的临床疗效，但可提高患者生存质量，降低发热、胃肠道反应和骨髓抑制的发生率。

    参芪扶正注射液；原发性肝癌；肝动脉栓塞化疗；随机对照试验；Meta分析；疗效；安全性

    ABSTRACTOBJECTIVE：To evaluate the effectiveness and safety of Shenqi fuzheng injection assisting TACE in the adjuvant treatment of primary liver carcinoma，and to provide evidence-based reference.METHODS：Retrieved from CJFD，Wanfang database，VIP and PubMed，randomized controlled trials(RCTs)about Shenqi fuzheng injection assisting TACE(trial group)vs.TACE alone(control group)in the treatment of primary liver carcinoma were collected.Meta-analysis was performed by using Stata 12.0 software after data extraction and quality evaluation according to improved Jadad scale.RESULTS：A total of 8 RCTs were included ......