野黄芩苷对血管紧张素Ⅱ诱导的新生大鼠心肌成纤维细胞的增殖及ERK1/2、p38 MAPK信号通路的影响(4)
参考文献
[ 1 ] SEGURA AM， FRAZIER OH， BUJA LM. Fibrosis and heart failure[J]. Heart Fail Rev，2014，19(2)：173-185.
[ 2 ] FAN D. Cardiac fibroblasts， fibrosis and extracellular matrix remodeling in heart disease[J]. Fibrogenesis Tissue Repair，2012，5(1)：15-28.
[ 3 ] KONG P， CRISTIA P， FRANGOGIANNIS NG. The pa- thogenesis of cardiac fibrosis[J]. Cell Mol Life Sci， 2014，71(4)：549-574.
, http://www.100md.com
[ 4 ] 宋秉春，张金国.心肌纤维化发病机制及治疗进展[J].济宁医学院学报，2015，5(1)：65-67.
[ 5 ] PORTER KE， TURNER NA. Cardiac fibroblasts：at the heart of myocardial remodeling[J]. Pharmacol Ther， 2009，123(2)：255-278.
[ 6 ] HU J，WANG X，WEI SM，et al. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways[J]. Eur J Pharmacol，2016，15(789)：319-327.
[ 7 ] XU Y，XIAO H，CHEN Y，et al. Inhibitory effects of oxymatrine on TGF-β1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways[J]. Mol Med Rep，2017，16(4)：5354-5362.
, 百拇医药
[ 8 ] GAO JL， CHEN G， HE HQ， et al. Therapeutic effects of breviscapine in cardiovascular diseases： a review[J]. Front Pharmacol，2017，23(8)：289-302.
[ 9 ] 范海. PDGFR-β/PI3K/AKT信号通路在PDGF-BB诱导大鼠心肌成纤维细胞所致心肌纤维化中的作用[D].合肥：安徽医科大学，2015.
[10] MUSLIN AJ. MAPK signaling in cardiovascular health and disease： molecular mechanisms and therapeutic targets[J]. Clin Sci (Lond)，2008，115(7)：203-218.
[11] STOCKAND JD， MESZAROS JG. Aldosterone stimulates proliferation of cardiac fibroblasts by activating KiRasA and MAPK signaling[J]. Am J Physiol Heart Circ Physiol，2003，284(1)：H176-H184.
, 百拇医药
[12] MACLEAN J， PASUMARTHI KB. Signaling mechanis- ms regulating fibroblast activation， phenoconversion and fibrosis in the heart[J]. Indian J Biochem Biophys，2014，51(6)：476-482.
[13] YEH CC， LI H， MALHOTRA D， et al. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse[J]. J Cell Biochem，2010，109(6)：1185-1191.
[14] BIERNACKA A， DOBACZEWSKI M， FRANGOGIA- NNIS NG. TGF?β signaling in fibrosis[J]. Growth Factors，2011，29(5)：196-202.
[15] ZHOU H， CHEN X， CHEN LZ， et al. Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats[J]. Molecules，2014，19(10)：15611-15623.
(收稿日期：2017-08-08 修回日期：2017-12-01)
(编辑：林 静), 百拇医药(辛博 陈力 万丽丽 郭澄)
[ 1 ] SEGURA AM， FRAZIER OH， BUJA LM. Fibrosis and heart failure[J]. Heart Fail Rev，2014，19(2)：173-185.
[ 2 ] FAN D. Cardiac fibroblasts， fibrosis and extracellular matrix remodeling in heart disease[J]. Fibrogenesis Tissue Repair，2012，5(1)：15-28.
[ 3 ] KONG P， CRISTIA P， FRANGOGIANNIS NG. The pa- thogenesis of cardiac fibrosis[J]. Cell Mol Life Sci， 2014，71(4)：549-574.
, http://www.100md.com
[ 4 ] 宋秉春，张金国.心肌纤维化发病机制及治疗进展[J].济宁医学院学报，2015，5(1)：65-67.
[ 5 ] PORTER KE， TURNER NA. Cardiac fibroblasts：at the heart of myocardial remodeling[J]. Pharmacol Ther， 2009，123(2)：255-278.
[ 6 ] HU J，WANG X，WEI SM，et al. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways[J]. Eur J Pharmacol，2016，15(789)：319-327.
[ 7 ] XU Y，XIAO H，CHEN Y，et al. Inhibitory effects of oxymatrine on TGF-β1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways[J]. Mol Med Rep，2017，16(4)：5354-5362.
, 百拇医药
[ 8 ] GAO JL， CHEN G， HE HQ， et al. Therapeutic effects of breviscapine in cardiovascular diseases： a review[J]. Front Pharmacol，2017，23(8)：289-302.
[ 9 ] 范海. PDGFR-β/PI3K/AKT信号通路在PDGF-BB诱导大鼠心肌成纤维细胞所致心肌纤维化中的作用[D].合肥：安徽医科大学，2015.
[10] MUSLIN AJ. MAPK signaling in cardiovascular health and disease： molecular mechanisms and therapeutic targets[J]. Clin Sci (Lond)，2008，115(7)：203-218.
[11] STOCKAND JD， MESZAROS JG. Aldosterone stimulates proliferation of cardiac fibroblasts by activating KiRasA and MAPK signaling[J]. Am J Physiol Heart Circ Physiol，2003，284(1)：H176-H184.
, 百拇医药
[12] MACLEAN J， PASUMARTHI KB. Signaling mechanis- ms regulating fibroblast activation， phenoconversion and fibrosis in the heart[J]. Indian J Biochem Biophys，2014，51(6)：476-482.
[13] YEH CC， LI H， MALHOTRA D， et al. Distinctive ERK and p38 signaling in remote and infarcted myocardium during post-MI remodeling in the mouse[J]. J Cell Biochem，2010，109(6)：1185-1191.
[14] BIERNACKA A， DOBACZEWSKI M， FRANGOGIA- NNIS NG. TGF?β signaling in fibrosis[J]. Growth Factors，2011，29(5)：196-202.
[15] ZHOU H， CHEN X， CHEN LZ， et al. Anti-fibrosis effect of scutellarin via inhibition of endothelial-mesenchymal transition on isoprenaline-induced myocardial fibrosis in rats[J]. Molecules，2014，19(10)：15611-15623.
(收稿日期：2017-08-08 修回日期：2017-12-01)
(编辑：林 静), 百拇医药(辛博 陈力 万丽丽 郭澄)