陈圣洁 东蕾 蒋春颖 姜海燕 徐梅先

    中图分类号 R956 文献标志码 A 文章编号 1001-0408(2018)13-1810-06

    DOI 10.6039/j.issn.1001-0408.2018.13.20

    摘 要 目的：评价磷酸奥司他韦颗粒剂联合蒲地蓝消炎口服液治疗儿童流感疑似病例的有效性和经济性。方法：采用实际临床试验(PCT)设计方法，将180例儿童流感疑似病例随机分为对照组和试验组，每组90例。对照组口服磷酸奥司他韦颗粒剂，试验组在此基础上加服蒲地蓝消炎口服液。收集患儿的临床效果和成本数据，从患者角度进行成本-效果分析，运用多元线性回归和二元Logistic回歸分别对成本和效果进行敏感度分析。结果：实际纳入对照组80例、试验组82例。两组患儿的临床有效率分别是80.00%、95.12%，不良反应发生率、合并用药(除联用抗生素外)、依从性等差异均无统计学意义(P>0.05)；平均药品成本分别是119.27、171.82元，平均总成本分别是203.46、257.03元；药品的增量成本-效果比(ICER)为347.55，总成本的ICER为354.30。敏感度分析结果与基础分析一致。结论：磷酸奥司他韦颗粒剂联合蒲地蓝消炎口服液治疗儿童流感疑似病例的疗效优于磷酸奥司他韦颗粒剂单用，但是磷酸奥司他韦颗粒剂单用更具有经济性。

    关键词 流感；儿童；磷酸奥司他韦颗粒剂；蒲地蓝消炎口服液；成本效果分析

    ABSTRACT OBJECTIVE： To evaluate the effectiveness and economics of Oseltamivir phosphate granules combined with Pudilan xiaoyan oral liquid in the treatment of suspected case of children influenza. METHODS： A pragmatic clinical trial (PCT)was conducted. A total of 180 suspected case of children influenza were randomly divided into control group and trial group， with 90 cases in each group. Control group was given Oseltamivir phosphate granules orally. Trial group was additionally given Pudilan xiaoyan oral liquid on the basis of control group. Clinical effects and cost data of children were collected. Cost-effectiveness analysis was conducted from a point of view of the patient. Sensitivity analysis of cost and effectiveness was conducted by multiple linear regression and binary Logistic regression. RESULTS： Totally 80 cases were included in control group ......