袁进 刘贺萍 许百虹 梁虹艺 杨晨 李健 董俪雯 曾颖

    摘 要 目的：为临床合理使用抗高血压药物提供参考。方法：利用处方点评系统，随机抽取2016年1-12月广东省人民医院心血管内科门诊处方中含抗高血压药物的处方进行回顾性研究，统计患者的性别、年龄、诊断结果、使用的抗高血压药物名称及其药理学分类等，将抗高血压药物联用情况与国内、外高血压防治指南中推荐的方案进行比较，评价其合理性。结果与结论：共收集含抗高血压药物的处方4 308份，其中联用处方2 183份，占纳入处方的50.67%。联用处方中，以二联为主，有1 420份，占联用处方的65.05%；以含血管紧张素Ⅱ受体阻滞药的处方最多，占联合用药处方的74.94%；符合指南推荐方案的联用处方有1 627份，占聯合用药处方的74.53%；不合理联用处方有420份，占联用处方的19.24%。其中指南未推荐的联用处方，因为缺乏详细的患者病历资料，其有效性和安全性有待进一步验证。

    关键词 处方；抗高血压药物；联合用药；指南

    ABSTRACT OBJECTIVE： To provide reference for rational use of antihypertensive drugs in clinic. METHODS： In retrospective study， antihypertensive drug prescriptions were randomly selected from cardiovascular medicine department of Guangdong Provincial Peoples Hospital during Jan.-Dec. 2016， by using prescription comment system. The patients gender， age， diagnosis， name and pharmacological classification of antihypertensive drugs were counted. Combined use of antihypertensive drugs was compared with the plan recommended by domestic and foreign hypertensive prevention and treatment guidelines. The rationality of antihypertensive drug use was evaluated. RESLUTS & CONCLUSIONS： Totally 4 308 prescriptions of antihypertensive drugs were collected ......