王玮 肖颖

    中图分类号 R914.2 文献标志码 A 文章编号 1001-0408(2018)19-2622-04

    DOI 10.6039/j.issn.1001-0408.2018.19.07

    摘 要 目的：制备头孢丙烯掩味微丸，优化其丸芯处方工艺。方法：采用粉末层积离心造粒法载药制备头孢丙烯丸芯，以黏合剂浓度、喷浆转速和供粉速度为因素，以粒径分布、收率、脆碎度、休止角和平面临界角的综合评分为指标，采用正交试验优化头孢丙烯丸芯的处方与工艺；所得丸芯以滑石粉、聚丙烯酸树脂和甜橙香精行掩味包衣，评价口感和累积溶出度。结果：头孢丙烯丸芯的最优处方工艺为黏合剂浓度3%、喷浆转速15 r/min、供粉速度30 r/min；所制头孢丙烯丸芯40～50目粒径分布94.0%，收率(92.1±2.9)%，脆碎度(1.1±0.1)%，休止角(23.2±0.4) °，平面临界角(6.5±0.4) °(n=3)。包衣后头孢丙烯掩味微丸无苦感，在45 min内的头孢丙烯累积溶出度超过85%。结论：成功制得頭孢丙烯掩味微丸，其中头孢丙烯丸芯优化后处方合理。

    关键词 头孢丙烯；微丸；掩味；离心造粒；综合评分；正交试验

    ABSTRACT OBJECTIVE： To prepare Cefprozil bitter-masked pellets， and optimize its pellet core. METHODS： Pellet core of cefprozil were prepared by powder layering with centrifugal granulation， using adhesive concentration， guniting rotation speed and supplying powder speed as factors， comprehensive score of particle size distribution， yield， friability， repose angle and plane critical angle as indexes， the orthogonal test was used to optimize the formulation and technology of pellet core of cefprozil. Then the bitter of pellet core was masked by coating with talcum powder ......