中图分类号R965 文献标志码A 文章编号 1001-0408(2025)08-0939-06

    DOI 10.6039/j.issn.1001-0408.2025.08.08

    Effct and mechanism of bumetanide on lung injury in chronic obstructive pulmonary disease model rats LEI ，LU Jing'， HE Wenjuan2，GU Jiaying'， ZHOU Dengfeng'(1. Dept. of Respiratory and Critical Care Medicine， Wuhan Fourth Hospital， Wuhan 43O033， China； 2. Dept. of Pharmacy， Wuhan Fourth Hospital， Wuhan ，China)

    ABSTRACTOBJECTIVE Toinvestigate the efect and mechanism of bumetanide on lung injury in chronicobstructive pulmonary disease(COPD)modelrats.METHODs COPD ratmodel was induced by lipopolysaccharide，and they were randomly divied into model group(COPD group)，bumetanide low-dose and high-dose groups (Bumetanide-L group，Bumetanide-H group)，bumetanidehigh-dose+Yes-associatedprotein/transcriptionalcoactivatorcontainingPDZ-bindingmotif(YAP/TAZ) signalingpathwayactivatorgroup(Bumetanide-H+PY-60group)，with12ratsineachgroupAnother12normalratswere selected asnormalcontrolgroup(Control group).Thirtyminutesbeforemodeling ......