中图分类号R969.3；R587 文献标志码A 文章编号 1001-0408(2025)08-0956-05

    DOI 10.6039/j.issn.1001-0408.2025.08.11

    Signal mining and analysis of adverse drug events of tirzepatide

    XIE Zeyu'，LIANG Zhuoru'，ZHENG Guimei，CAO Weiling，CHEN Jisheng2(1. Dept. of Pharmacy， Shenzhen Luohu People's Hospital， Guangdong Shenzhen 5180Oo， China；2. Key Specialty of Clinical Pharmacy， the First Affiliated Hospital of Guangdong Pharmaceutical University， Guangzhou 510o80， China)

    ABSTRACTOBJECTIVEToidentify andanalyzeadversedrug event(ADE)signalsassciatedwithtirzepatidebasedonthe FDAAdverse Event Reporting System(FAERS)database，providingareference forclinicalmedication safetyMETHODS ADE reportsfromJanuaryl，2022，toJune302024，withtirzepatideastheprimarysuspecteddrug，wereextractedfromtheFAERS databae.MedicalDictionaryforRegulatoryActivitieswasusedtosystematicallycategorizetheselectedsystemorganclass(SOC) and preferredtermofADE.Signalmining andanalysis were performedusingthereportingoddsratiomethodandthepropotional reportingratiomethodRESULTSAtotalof39229ADEreportsrelatedtotirzepatidewerebtained，including3934severe ADE reports( 10.03% ). The majority of severe ADE reports were related to hospitalization or prolonged hospitalization( 3.82% ......