中图分类号 R979.1 文献标志码 A 文章编号 1001-0408(2025)10-1248-06

    DOI 10.6039/j.issn.1001-0408.2025.10.17

    One case report and literature review of severe cardiotoxicity by oxaliplatin combined with capecitabine XU Lina1， 2，FANG Yingli1，WANG Xiangling3，DU Pengcheng2(1. Dept. of Clinical Pharmacy，Qilu Hospital of Shandong University，Jinan ，China；2. Dept. of Clinical Pharmacy，Dezhou Hospital，Qilu Hospital of Shandong University，Shandong Dezhou 253000，China；3. Dept. of Oncology，Qilu Hospital of Shandong University，Jinan ，China)

    ABSTRACT OBJECTIVE To explore the relationship between severe cardiotoxicity caused by oxaliplatin combined with capecitabine and genetic polymorphism， thereby providing references for safe clinical medication use. METHODS Clinical pharmacists conducted a correlation analysis on a case of severe cardiotoxicity in a rectal cancer patient at Qilu Hospital of Shandong University following first-time treatment with standard doses of oxaliplatin combined with capecitabine. Case reports of cardiotoxicity caused by oxaliplatin and capecitabine were retrieved from the Chinese and English databases such as CNKI and PubMed.Basic patient information ......