中图分类号 R965；R285.5 文献标志码 A 文章编号 1001-0408(2025)10-1186-05

    DOI 10.6039/j.issn.1001-0408.2025.10.06

    Mechanism of Buyang huanwu tang in improving idiopathic pulmonary fibrosis by delaying cellular senescence

    CHEN Long，QU Jinglian(College of Basic Traditional Chinese Medicine，Guizhou University of TraditionalChinese Medicine，Guiyang ，China)

    ABSTRACT OBJECTIVE To investigate the improvement effect and mechanism of Buyang huanwu tang on idiopathic pulmonary fibrosis(IPF)model rats. METHODS The rats were randomly divided into normal group，model group，pirfenidone group(positive control， )，Buyang huanwu tang low- ，medium- and high-dose groups (6.435，12.87，25.749/kg) ， with 6 rats in each group. Except for the normal group，IPF model was established in the remaining groups by intratracheal injection of bleomycin sulfate. On the second day after successful modeling ......