中图分类号 R285.5；R917 文献标志码 A 文章编号 1001-0408(2025)10-1197-05

    DOI 10.6039/j.issn.1001-0408.2025.10.08

    Study on toxicity-reducing and efficacy-enhancing effects of Polygala tenuifolia compatibility on sandironing Strychnos nux-vomica

    SUI Yi¹ ，FENG Guo1， 2， 3，LIU Gang1，LIU Keyan1，WEI Xuehao1，TENG Minggang1，LI Wei1， 2，HAN Caiyao1， LEI Yan¹ (1. College of Pharmacy，Guizhou University of Traditional Chinese Medicine，Guiyang 550025， China；2. Guizhou Traditional Chinese Medicine Processing Technology Inheritance Base，Guiyang 550025， China；3. National Key Laboratory of Authentic Medicinal Materials，Beijing 100700，China)

    ABSTRACT OBJECTIVE To explore the effects of Polygala tenuifolia compatibility on toxicity， anti-inflammatory and analgesic efficacy of sand-ironing Strychnos nux-vomica(SS). METHODS The preparation of SS single decoction，SS-P. tenuifolia core-removed(PC)(1∶2.5)or (1：5) combined decoction，and SS-PC(1∶5)mixture were carried out to investigate their median lethal dose( ΔLD₅₀ ). Using aspirin as positive control，the number of writhing movements ......