中图分类号 R965 文献标志码 A 文编号 1001-0408(2025)10-1172-07

    DOI 10.6039/j.issn.1001-0408.2025.10.04

    Exploration of the antidepressant mechanism of Shugan hewei tang based on metabolomics of PFC-NAcVTA neural circuit

    QU Xinyue1，HU Junjie1，LI Juan1，ZHANG Min¹ ，ZHOU Xian2，LIU Songlin2，CHEN Chi dotmathbf "imathbf"n scriptscriptstyle "(1. Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine，Hubei University of Chinese Medicine，Wuhan ， China；2. Clinical College of Chinese Medicine， Hubei University of Chinese Medicine，Wuhan ，China)

    ABSTRACT OBJECTIVE To investigate the antidepressant mechanism of Shugan hewei tang (SGHWT) based on the metabolomics of prefrontal cortex (PFC)-nucleus accumbens (NAc)-ventral tegmental area (VTA) neural circuit. METHODS Male SD rats were randomly divided into blank group，model group，SGHWT low-，medium- and high-dose groups [3.67，7.34， 14.68g/(kg?d) ，by raw material]，and fluoxetine group [1.58mg/(kg?d) ，positive control]，with 12 rats in each group. Except for the blank group ......