中图分类号 R956 文献标志码 A 文章编号 00-0408(05)0-09-07

    DOI 0.609/j.issn.00-0408.05.0.0

    Cost-effectiveness of vitamin D analogue for postmenopausal osteoporosis in women

    GUAN Haijing1，XU Yanan1， 2，ZHAO Zhigang1，FAN Changsheng3(1. Dept. of Pharmacy，Beijing Tiantan Hospital，Capital Medical University，Beijing ，China；2. School of Pharmaceutical Sciences，Capital Medical University，Beijing ，China；3. Beijing Medical and Health Economic Research Association， Beijing ，China)

    ABSTRACT OBJECTIVE To evaluate the cost-effectiveness of vitamin D analogue for postmenopausal osteoporotic women in China. METHODS A Markov microsimulation model was developed to analyze the clinical and economic outcomes of eldecalcitol， alfacalcidol and calcitriol for postmenopausal osteoporosis from the healthcare system perspective in China. The clinical parameters required for the model were derived from network meta-analysis，while cost and utility data were primarily obtained from the literature. The cycle length was 1 year ，the time horizon was life time，and the willingness-to-pay threshold was 0.5 times the gross domestic product per capita in China in 2023(44 679 yuan/QALY). Model uncertainty was tested with one-way sensitivity analysis ......