中图分类号 R943；R283 文献标志码 A 文章编号 1001-0408(2025)11-1329-06

    DOI 10.6039/j.issn.1001-0408.2025.11.07

    ABSTRACT OBJECTIVE To optimize the forming process of Yindan huoxue tongyu granules，and evaluate the quality of the granules. METHODS Taking forming rate，angle of repose，moisture，moisture absorption rate and dissolution rate as indexes， single factor experiment combined with Plackett-Burman design was adopted to screen key process parameters；analytic hierarchy process combined with entropy weight method and Box-Behnken response surface method were used to optimize the molding process of Yindan huoxue tongyu granules，and the forming process was verified. The relative homogeneity index，bulk density， vibration density，Hausner ratio，angle of repose，moisture and hygroscopicity were used as secondary physical indexes to establish the physical fingerprints of 10 batches of Yindan huoxue tongyu granules to evaluate particle quality consistency. RESULTS The optimal molding process of Yindan huoxue tongyu granules was as follows：mannitol as the fixed excipient ......